234429-91-5

Upstream product

• 91-95-2 3,3',4,4'-tetraaminobiphenyl 
• 86516-51-0 1-(4-methoxyphenyl)-2-tosylethanone 
• 2632-13-5 2-Bromo-4'-methoxyacetophenone 
• 123-11-5 4-methoxy-benzaldehyde 

Relevant academic research and scientific papers

Synthesis of 2-arylbenzimidazole analogues

Substituted 2-arylbenzimidazoles (4) were easily synthesized in good yields starting from the condensation reaction of 1,2-diaminobenzenes (1) with β-ketosulfones (5) in the presence of boiling HOAc.

BIS-BENZIMIDAZOLE COMPOUNDS AND METHODS OF USING SAME

Provided herein are compounds and methods for modulating abnormal repeat expansions of gene sequences. More particularly, provided are inhibitors of RNA and the uses of such inhibitors in regulating nucleotide repeat expansions, e.g., to treat Myotonic Dystrophy Type 1 (DM1 ), Myotonic Dystrophy Type 2 (DM2), Fuchs dystrophy, Huntington Disease, Amyotrophic Lateral Sclerosis, or Frontotemporal Dementia.

ANTIBACTERIAL COMPOUNDS

Disclosed are compounds of formula (I), which are of use in the treatment of bacterial diseases and infections, to compositions containing those compounds and to methods of treating bacterial diseases and infections using the compounds. In particular, the compounds are useful for the treatment of infection with, and diseases caused by, Clostridium difficile.