23465-75-0Relevant academic research and scientific papers
Regioselective syntheses of 3-hydroxy-4-aryl-3,4,5-trihydro-2H-benzo[b][1,4]diazepin-2(1H)-ones and 3-benzylquinoxalin-2(1H)-ones from arylglycidates when exposed to 1,2-diaminobenzenes
Mamedov, Vakhid A.,Mamedova, Vera L.,Syakaev, Victor V.,Voronina, Julia K.,Mahrous, Essam M.,Korshin, Dmitry E.,Latypov, Shamil K.,Sinyashin, Oleg G.
, (2020/09/10)
Representatives of two pharmacologically significant classes of compounds – 3-hydroxy-4-aryl-3,4,5-trihydro-2H-benzo[b][1,4]diazepin-2(1H)-ones and 3-benzylquinoxalin-2(1H)-ones – obtained in reactions of 1,2-diaminobenzenes with methyl 3-arylglycidates in boiling acetic acid. Substituents in arylglycidates determine the direction of processes. Electron withdrawing substituents (NO2), halogen atoms (Cl, Br, F), as well as the absence of substituents, provide the formation of benzo[b][1,4]diazepin-2(1H)-one derivatives, and electron donating groups (OMe, Me) contribute to the formation of 3-benzylquinoxalin-2(1H)-ones. As a result, a new rare representatives of 3-hydroxy-4-aryl-3,4,5-trihydro-2H-benzo[b][1,4]diazepin-2(1H)-ones were obtained and a new method for producing 3-benzylquinoxalin-2(1H)-ones has been proposed.
Microwave-assisted solvent-dependent reaction: Chemoselective synthesis of quinoxalin-2(1 H)-ones, benzo[ d]imidazoles and dipeptides
Wang, Shu-Liang,Ding, Jie,Jiang, Bo,Gao, Yuan,Tu, Shu-Jiang
, p. 572 - 577 (2011/11/06)
A microwave-assisted solvent-dependent chemoselective reaction dealing with 4-arylidene-2-phenyloxazol-5-ones and diverse ortho-diamines to achieve three types of molecular scaffolds, 3-benzylquinoxalin-2(1H)-ones, benzimidazole and β-amino dipeptides is
Novel 3-benzoyl-2-piperazinylquinoxaline derivatives as potential antitumor agents
Piras, Sandra,Loriga, Mario,Carta, Antonio,Paglietti, Giuseppe,Costi, M. Paola,Ferrari, Stefania
, p. 541 - 548 (2007/10/03)
A series of new benzoylquinoxaline derivatives (7-26) was synthesized and evaluated for antitumor activity against a panel of 60 human cell lines at the NCI of Bethesda. Among the compounds which have passed the preliminary screening, compound 23 exhibite
Condensation of o-Phenylenediamines with Azlactones
Subhashini, N. J. Prameela,Hanumanthu, P.
, p. 32 - 35 (2007/10/02)
Condensation of o-phenylenediamines (I) with 4-arylidene-2-substituted-oxazolin-5-ones (II) (azlactones) in acetic acid results in the formation of 3-benzyl-2(1H)quinoxalinones (III) and substituted benzimidazoles (IV).Structures of these compounds have been established based on their spectral data, and direct comparison with authentic samples prepared by unambiguous routes.
