23471-70-7Relevant academic research and scientific papers
Copper- and palladium-containing perovskites: Catalysts for the Ullmann and Sonogashira reactions
Lohmann, Sophie,Andrews, Stephen P.,Burke, Brenda J.,Smith, Martin D.,Attfield, J. Paul,Tanaka, Hirohisa,Kaneko, Kimiyoshi,Ley, Steven V.
, p. 1291 - 1295 (2007/10/03)
The utility of perovskite-based materials in organic synthesis is explored through examination of a series of copper- and palladium-containing perovskites in Ullmann and Sonogashira type reactions. La0.9Ce 0.1Co0.6Cu0.4O3 is identified as an effective catalyst for the synthesis of a range of biaryl ether and thioether functionalities, whilst a Cu- and Pd-containing perovskite is effective in the Sonogashira reaction. These results suggest that perovskites may be useful leads in the search for new catalysts and reagents for organic synthesis.
Synthesis and structure-activity relationships of trisubstituted phenyl urea derivatives as neuropeptide Y5 receptor antagonists
Fotsch,Sonnenberg,Chen,Hale,Karbon,Norman
, p. 2344 - 2356 (2007/10/03)
1-((1R,2R)-2-Hydroxy-1-methyl-2-phenylethyl)-1-methyl-3-(4-phenoxyphenyl)urea (1) was identified as a hit from the screening of the neuropeptide Y5 (NPY5) receptor. This lead was optimized for in vitro potency by changing the stereochemistry, the phenylethyl segment, the urea portion, and the 4-phenoxyphenyl group on the molecule. Over 40 analogues of 1 were prepared to study the structure-activity relationship for this series. The most potent compounds in this class have IC50S less than 0.1 nM at the NPY5 receptor (e.g., 40f, 44a, and 47). To determine the functional activity for this series of compounds, selected analogues were tested in a cellular assay measuring forskolin-induced cyclic AMP accumulation in 293 cells transfected with the human NPY5 receptor. All urea analogues tested in the functional assay acted as antagonists (e.g., 1, 32, 40a, and 44e).
