2348-02-9Relevant articles and documents
Enantioselective Oxidative Aerobic Dealkylation of N-Ethyl Benzylisoquinolines by Employing the Berberine Bridge Enzyme
Gandomkar, Somayyeh,Fischereder, Eva-Maria,Schrittwieser, Joerg H.,Wallner, Silvia,Habibi, Zohreh,Macheroux, Peter,Kroutil, Wolfgang
, p. 15051 - 15054 (2016/01/25)
N-Dealkylation methods are well described for organic chemistry and the reaction is known in nature and drug metabolism; however, to our knowledge, enantioselective N-dealkylation has not been yet reported. In this study, exclusively the (S)-enantiomers o
Biocatalytic enantioselective oxidative C-C coupling by aerobic C-H activation
Schrittwieser, Joerg H.,Resch, Verena,Sattler, Johann H.,Lienhart, Wolf-Dieter,Durchschein, Katharina,Winkler, Andreas,Gruber, Karl,MacHeroux, Peter,Kroutil, Wolfgang
, p. 1068 - 1071 (2011/04/22)
Bridging the gap: The berberine bridge enzyme (BBE) was employed for the first preparative oxidative biocatalytic C-C coupling that leads to a new intramolecular bond. This unique transformation requires O2 as sole stoichiometric oxidant and gives access to novel optically pure (S)-berbine 2 and (R)-1-benzyl-1,2,3,4-tetrahydroisoquinoline 1 alkaloid derivatives by kinetic resolution.
(R)-(+)-NORANICANINE A NEW TYPE OF TRIOXYGENATED BENZYLISOQUINOLINE ISOLATION AND SYNTHESIS
Oger, Jean Michel,Duval, Olivier,Richomme, Pascal,Bruneton, Jean,Guinaudeau, Helene,Fournet, Alain
, p. 17 - 20 (2007/10/02)
(R)-(+)-Noranicanine (1a), a new type of benzylisoquinoline precursor was isolated from Aniba canelilla (Lauraceae) and its structure was determined by means of spectroscopic data as well as by synthesis.
