23491-44-3

Basic information

• Product Name: HOECHST 33258
• Synonyms: 4-(5-(4-methyl-1-piperazinyl)(2,5’-bi-1h-benzimidazol)-2’-yl)-pheno;4-[6'-(4-Methylpiperazino)-6,2'-bi[1H-benzimidazole]-2-yl]phenol;4-[6-[6-(4-Methylpiperazino)-1H-benzimidazole-2-yl]-1H-benzimidazole-2-yl]phenol;Bisbenzimidazol;4-[5-(4-methyl-1-piperazinyl)[2,5’-bi-1h-benzimidazol]-2’-yl]-pheno;bisbenzimidazole;p-(5-(5-(4-methyl-1-piperazinyl)-2-benzimidazolyl)-2-benzimidazolyl)-pheno;pibenzimol
• CAS NO: 23491-44-3
• Molecular Formula: C₂₅H₂₄N₆O
• Molecular Weight: 424.5
• EINECS: 245-690-6
• Mol File: 23491-44-3.mol
• Article Data: 2

Chemical Properties

• Melting Point: 314 °C
• Boiling Point: 643.1 °C at 760 mmHg
• Flash Point: 342.7 °C
• Appearance: /powder
• Density: 1.337 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.742
• Storage Temp.: −20°C
• Solubility: H2O: 10 mg/mL
• PKA: 9.23±0.15(Predicted)
• Stability: Stable. Incompatible with strong oxidizing agents. Light sensitive.
• CAS DataBase Reference: HOECHST 33258(CAS DataBase Reference)
• NIST Chemistry Reference: HOECHST 33258(23491-44-3)
• EPA Substance Registry System: HOECHST 33258(23491-44-3)

Safety Data

• Hazard Codes: Xn
• Statements: 22-36/38
• Safety Statements: 26-36
• WGK Germany: 3
• RTECS: SM1140500
• F: 3-8-10
• Hazardous Substances Data: 23491-44-3(Hazardous Substances Data)

Usage

Chemical Properties

yellow solid

InChI:InChI=1/C25H24N6O/c1-30-10-12-31(13-11-30)18-5-9-21-23(15-18)29-25(27-21)17-4-8-20-22(14-17)28-24(26-20)16-2-6-19(32)7-3-16/h2-9,14-15,32H,10-13H2,1H3,(H,26,28)(H,27,29)

Downstream Products

• 756470-95-8 ethyl Ho₃₃₂₅₈-O-butyrate 
• 682809-60-5 Ho₃₃₂₅₈-O-butyric acid 
• 106050-84-4 monoiodoHoechst 33258 

Relevant articles and documents

DNA-targeted alkylating agents

The invention relates to novel bis-benzimidazole compounds which have the ability to bind to the minor groove of DNA and to alkylate DNA, to methods of preparing the compounds, and the use of the compounds in the treatement of neoplastic disease.