235098-83-6

Upstream product

• 1150313-02-2 C₂₀H₃₄O₃Si 
• 235098-93-8 dithiocarbonic acid O-(4-benzyl-6-benzyloxymethyl-2,2-dimethyl-[1,3]dioxan-5-yl) ester S-methyl ester 
• 235098-92-7 (4S,6S)-4-Benzyl-6-benzyloxymethyl-2,2-dimethyl-[1,3]dioxan-5-ol 
• 219746-02-8 (4S,6S)-4-Benzyl-6-benzyloxymethyl-2,2-dimethyl-[1,3]dioxan-5-one 
• 126178-04-9 [(S)-4-Benzyl-2,2-dimethyl-[1,3]dioxan-(5E)-ylidene]-((S)-2-methoxymethyl-pyrrolidin-1-yl)-amine 
• 126178-07-2 (S)-(+)-1-(2,2-dimethyl-1,3-dioxan-5-ylidenamino)-2-methoxymethylpyrrolidine 
• 100-39-0 benzyl bromide 

Downstream Products

• 235098-84-7 4-Nitro-benzenesulfonic acid (4R,6S)-6-benzyl-2,2-dimethyl-[1,3]dioxan-4-ylmethyl ester 
• 1150313-03-3 C₁₄H₁₈O₃ 
• 235098-86-9 (4S,6S)-4-((4R,6S)-6-Benzyl-2,2-dimethyl-[1,3]dioxan-4-ylmethyl)-6-benzyloxymethyl-2,2-dimethyl-[1,3]dioxan-5-one 
• 235098-87-0 C₂₈H₃₈O₅ 
• 235098-89-2 C₂₁H₃₁IO₄ 
• 235098-88-1 [(4R,6S)-6-((4R,6S)-6-Benzyl-2,2-dimethyl-[1,3]dioxan-4-ylmethyl)-2,2-dimethyl-[1,3]dioxan-4-yl]-methanol 
• 235098-85-8 (4S,6R)-4-Benzyl-6-iodomethyl-2,2-dimethyl-[1,3]dioxane 

Relevant academic research and scientific papers

Chemoenzymatic asymmetric synthesis of harzia lactone A stereomers

A facile chemoenzymatic synthesis of the harzia lactone A enantiomers was developed. A lipase-catalyzed acylation and an enantio-controlled substrate and reagent-controlled Sharpless' asymmetric dihydroxylation are the key features of the synthesis.

Iterative asymmetric synthesis of protected anti-1,3-polyols

A new general method for the iterative asymmetric synthesis of anti-1,3-polyol chains has been developed. The α,α'-bisalkylation of 2,2-dimethyl-1,3-dioxan-5-one SAMP-hydrazone 1 with benzyloxymethylchloride as the second electrophile leads to virtually diastereo- and enantiopure substituted 2,2-dimethyl-1,3-dioxan-5-ones with good overall yields. Their deoxygenation and conversion into primary iodides affords the electrophile for the further alkylation of 1. In this way the configurations of all new stereogenic centres are controlled by a single auxiliary.