2351-90-8Relevant articles and documents
Synthesis and Biological Evaluation of Hoshionolactam-Based Compounds
Elizebath, Drishya,Jachak, Gorakhnath R.,Reddy, D. Srinivasa,Shanmugam, Dhanasekaran,Shukla, Anurag
, p. 2212 - 2218 (2021)
In search of novel antitrypanosomal agents based on hoshinolactam (IC50=3.9 nM), we disclose the synthesis and biological evaluations of 14 different analogues of the natural product using combinations of different acids and lactams. Antitrypanosomal activity assays revealed that the synthesized analogues were less potent than the parent natural product.
Experimental evidence for a [2 + 2] mechanism in the Lewis acid-promoted formation of α,β-unsaturated esters from ethoxyacetylene and aldehydes. Synthesis and characterisation of 4-ethoxyoxetes
Oblin, Magali,Parrain, Jean-Luc,Rajzmann, Michel,Pons, Jean-Marc
, p. 1619 - 1620 (1998)
4-Ethoxy-2H-oxetes 3a-c were prepared from ethoxyacetylene and alkoxy aldehydes 1a-c through MgBr2-Et2O promoted [2 + 2] cycloaddition reaction and were characterized at room temperature; their synthesis, which could occur via the formation of a chelate, establishes cycloaddition as the initial step in the formation of α,β-unsaturated esters 4a-c.
Phosphorus-recycling wittig reaction: Design and facile synthesis of a fluorous phosphine and its reusable process in the wittig reaction
Yamamoto, Yuki,Kawaguchi, Shin-Ichi,Nishimura, Misaki,Sato, Yuki,Shimada, Yoshihisa,Tabuchi, Akihiro,Nomoto, Akihiro,Ogawa, Akiya
, p. 14684 - 14696 (2020/11/30)
This study shows that phosphorus sources can be recycled using the appropriate fluorous phosphine in the Wittig reaction. The designed fluorous phosphine, which has an ethylene spacer between its phosphorus atom and the perfluoroalkyl group, was synthesized from air-stable phosphine reagents. The synthesized phosphine can be used for the Wittig reaction process to obtain various alkenes in adequate yields and stereoselectivity. The concomitantly formed fluorous phosphine oxide was extracted from the reaction mixture using a fluorous biphasic system. The fluorous phosphine was regenerated by reducing the fluorous phosphine oxide with diisobutylaluminum hydride. Finally, a series of gram scale phosphorus recycling processes were performed, which included the Wittig reaction, separation, reduction, and reuse.
Stereoselective Synthesis of C1–C7 and C6–C22 Fragments of Phostriecin, Goniothalamines, and Their Analogues
Purushotham Reddy,Vasudeva Reddy,Sabitha, Gowravaram
, p. 4389 - 4399 (2018/09/11)
The stereoselective synthesis of two fragments (C1–C7 and C6–C22) of the anti-tumor agent phostriecin has been achieved. The chiral hydroxy-vinyl-δ-lactone building block (fragment C1–C7) was subsequently utilized for the synthesis of 5-hydroxygoniothalamin, 5-acetoxygoniothalamin, and their derivatives.
