2425-25-4

Usage

InChI:InChI=1/C8H17O5PS/c1-4-11-8(9)7-15-14(10,12-5-2)13-6-3/h4-7H2,1-3H3

Upstream product

• 2524-04-1 diethyl phosphorochloridothioate 
• 105-39-5 chloroacetic acid ethyl ester 
• 1665-65-2 diethyl 2,2'-disulfanediyldiacetate 
• 762-04-9 phosphonic acid diethyl ester 
• 623-73-4 diazoacetic acid ethyl ester 
• 2465-65-8 O,O'-diethyl thiophosphoric acid 
• 623-51-8 ethyl 2-sulfanylacetate 
• 105-36-2 ethyl bromoacetate 
• 762-04-9 Diethyl phosphonate 

Downstream Products

• 42778-95-0 ethyl (E)-dodec-2-enoate 
• 7367-88-6 ethyl (E)-2-decenate 
• 7367-88-6 (Z)-dec-2-enoic acid ethyl ester 
• 2351-90-8 ethyl (2E)-oct-2-enoate 
• 42778-93-8 ethyl (Z)-oct-2-enoate 
• 17343-88-3 (E)-3-cyclohexyl-acrylic acid ethyl ester 

Relevant academic research and scientific papers

A Robust Methodology for the Synthesis of Phosphorothioates, Phosphinothioates and Phosphonothioates

A robust methodology for the synthesis of phosphorothioates, phosphinothioates and phosphonothioates, including those bearing low molecular weight S-alkyl side-chains, is presented. Application of the “caesium effect” in conjunction with the disulfide 3,3’-dithiobis(propionitrile), which acts as a shelf-stable sulfur source, avoids recourse to malodorous alkanethiols and toxic P?Cl precursors. A diverse range of sulfur-containing organophosphorus targets, including phosphorus-based heterocycles, may be prepared in consistently high yields. This chemistry also provides ready access to the corresponding DBU salts which are potential substrates for Pd-catalysed coupling reactions. (Figure presented.).

Cs2CO3-Catalyzed Aerobic Oxidative Cross-Dehydrogenative Coupling of Thiols with Phosphonates and Arenes

An efficient Cs2CO3-catalyzed oxidative coupling of thiols with phosphonates and arenes that uses molecular oxygen as the oxidant is described. These reactions provide not only a novel alkali metal salt catalyzed aerobic oxidation, but also an efficient approach to thiophosphates and sulfenylarenes, which are ubiquitously found in pharmaceuticals and pesticides. The reaction proceeds under simple and mild reaction conditions, tolerates a wide range of functional groups, and is applicable to the late-stage synthesis and modification of bioactive molecules.

A thiophosphate synthetic method of compound and the method in a plurality of pharmaceutical application in the synthesis of (by machine translation)

The invention discloses a having the general formula (III) of the thiophosphate synthetic method of compound, the purpose is to provide a novel, condition is simple, easy to industrial production of the thiophosphate synthetic method of compound. The method is to have the general formula (I) of the organophosphorus oxygen apperception compound having the general formula (II) with a mercaptan or phenyl-sulfhydryl apperception compound mixed, under the effects of catalyst, obtained by the reaction of the formula (III) of the thiophosphate compound. The method of the invention, can be cheap efficient synthesis of thiophosphate compounds, in actual production will have extensive application prospect. (by machine translation)