23516-76-9Relevant academic research and scientific papers
Synthesis of C- and N-Substituted 1,5,2,6-Dithiadiazocanes –Electrophilic-Nucleophilic Thioamination (ENTA) Reagents
Bagd?iūnas, Gintautas,Javorskis, Tomas,Jurys, Arminas,Orentas, Edvinas
supporting information, p. 3329 - 3335 (2021/07/02)
A synthetic method is presented for S?N bond formation starting from cheap and affordable materials. We show that (un)substituted N-protected cyclic eight-membered C2-symmetric sulfenamides have been prepared in a few steps using this procedure. The synthetic utility of these ambipolar derivatives was demonstrated in a variety of synthetic transformations affording different S,N-heterocyles of pharmaceutical relevance in one or two steps from simple starting materials. (Figure presented.).
N-Tosyl-1,5,2,6-dithiadiazocane: A waste-free electrophilic sulfur reagent for the efficient synthesis of medium-ring S,N-heterocycles
Javorskis, Tomas,Bagd?iunas, Gintautas,Orentas, Edvinas
supporting information, p. 4325 - 4328 (2016/03/22)
We report on the application of an eight-membered C2-symmetric sulfenamide derivative as a new convenient and highly reactive electrophilic sulfur-nucleophilic nitrogen synthon for the concise synthesis of medium-ring S,N-heterocyclic systems.
