23539-10-8

Upstream product

• 23538-88-7 N-benzyl-N,N-bis(2-phthalimidoethyl)amine 
• 112193-79-0 N³-benzyl-N¹,N⁵-ditosyl-3-aza-1,5-pentanediamine 
• 1370282-83-9 C₁₃H₂₁N₅O₂ 
• 6938-07-4 N,N-bis(2-ethoxycarbonylethyl)benzylamine 
• 100-46-9 benzylamine 
• 178552-62-0 N,N'-((benzylazanediyl)bis(ethane-2,1-diyl))bis(2,2,2-trifluoroacetamide) 
• 2851-60-7 N,N'-bis(salicylidene)diethylenetriamine 
• 100-44-7 benzyl chloride 
• 147688-20-8 3-Benzyl-1,5-bis(benzyloxycarbonylamino)-3-azapentane 

Downstream Products

• 91817-09-3 3-Benzyl-N,N'-dibutanoyl-3-aza-1,5-pentanediamine 
• 147714-34-9 10-Benzyl-1,4-dioxa-7,10,13-triazacyclopentadecane-5,13-dione 
• 178552-63-1 N,N'-[[(phenylmethyl)imino]di-2,1-ethanediyl]bis[N-[2-(1,1-dimethylethoxy)-2-oxoethyl]]glycine bis(1,1-dimethylethyl)ester 
• 91817-03-7 5,17-Dibenzyl-2,8,14,20-tetrabutyl-11,23-dichloro-2,5,8,10,12,14,17,20,22,24,25,26-dodecaaza-tricyclo[19.3.1.1^9,13]hexacosa-1⁽²⁵⁾,9,11,13⁽²⁶⁾,21,23-hexaene 
• 91817-13-9 N-Benzyl-N'-butyl-N-{2-[butyl-(4,6-dichloro-[1,3,5]triazin-2-yl)-amino]-ethyl}-N'-(4,6-dichloro-[1,3,5]triazin-2-yl)-ethane-1,2-diamine 
• 91817-11-7 N-Benzyl-N'-butyl-N-(2-butylamino-ethyl)-ethane-1,2-diamine 
• 147688-21-9 10-Benzyl-1,4-dioxa-7,10,13-triazacyclopentadecane 
• 688348-35-8 C₅H₃NCH₂OC₆H₄CH₂N(CH₂C₆H₅)CH₂CH₂N(CH₂C₆H₅)CH₂CH₂NHCH₂C₆H₄CH₂O 
• 112193-79-0 N³-benzyl-N¹,N⁵-ditosyl-3-aza-1,5-pentanediamine 
• 132066-05-8 N,N'-((benzylazanediyl)bis(ethane-2,1-diyl))dibenzenesulfonamide 
• 47090-93-7 Benzyl-bis-(2-guanidino-ethyl)-amin 

Relevant academic research and scientific papers

Dissecting the chloride-nitrate anion transport assay

A systematic study of chloride vs. nitrate selectivity across six anion transporters has revealed a good correlation between the selectivities of their anion binding and membrane transport properties. This work reveals the limitations of the chloride-nitrate exchange assay and shows how new approaches can be used to measure anion uniport.

Synthesis and characterization of N-substitutional ethylenediamine derivatives

N-Substituted and N,N-disubstituted ethylenediamine derivatives were prepared rapidly in aqueous conditions from 30 to 76 % yields, respectively, on a multi-gram scale starting from inexpensive and commercially available starting materials. The steps involved Michael addition, hydrazinolysis and Curtius rearrangements. The highlight of this method lies on its convenience and economy in accessing these intermediates.

New N-substituted polyamines. Synthesis, characterization and crystal and molecular structure of 2-[{C6H4(CO)2NCH 2CH2}2NCH2]C6H 4Br

New branched polyamines starting from diethylenetriamine, i.e. (Me 2NCH2CH2)2NCH2C 6H5 (9) and 2-[(Me2NCH2CH 2)2NCH2]C6H4X [X = Cl (10), Br (11)], were prepared by a multi-step procedure. Both the branched polyamines and the corresponding intermediates were characterized by multinuclear NMR spectroscopy in solution. The crystal and molecular structure of the intermediate 2-[{C6H4(CO)2NCH 2CH2}2NCH2]C6H 4Br (5) was established by single-crystal X-ray diffraction.

New 1H-Pyrazole-Containing Polyamine Receptors Able to Complex L-Glutamate in Water at Physiological pH Values

The interaction of the pyrazole-containing macrocyclic receptors 3,6,9,12,13,16,19,22,25,26-decaazatricyclo-[22.2.1.1 11,14]-octacosa-1(27),11,14(28),24-tetraene 1[L1], 13,26-dibenzyl-3,6,9,12,13,16,19,22,25,26-decaazatricyclo-[22.2.1.1 11,14]-octacosa-1(27),11,14(28),24-tetraene 2[L2], 3,9,12,13,16,22,25,26-octaazatricyclo-[22.2.1.1 11,14]-octacosa-1(27),11,14(28),24-tetraene 3[L3], 6,19-dibenzyl-3,6,9,12,13,16,19,22,25,26-decaazatricyclo-[22.2.1.1 11,14]-octacosa-1(27),11,14,(28),24-tetraene 4[L4], 6,19-diphenethyl-3,6,9,12,13,16,19,22,25,26-decaazatricyclo-[22.2.1.1 11,14]-octacosa-1(27),11,14(28),24-tetraene 5[L5], and 6,19-dioctyl-3,6,9,12,13,16,19,22,25,26-decaazatricyclo-[22.2.1.1 11,14]-octacosa-1(27),11,14(28),24-tetraene 6[L6] with L-glutamate in aqueous solution has been studied by potentiometric techniques. The synthesis of receptors 3-6[L3-L6] is described for the first time. The potentiometric results show that 4[L4] containing benzyl groups in the central nitrogens of the polyamine side chains is the receptor displaying the larger interaction at pH 7.4 (Keff = 2.04 × 104). The presence of phenethyl 5[L5] or octyl groups 6[L6] instead of benzyl groups 4[L4] in the central nitrogens of the chains produces a drastic decrease in the stability [Keff = 3.51 × 102 (5), Keff = 3.64 × 102 (6)]. The studies show the relevance of the central polyaminic nitrogen in the interaction with glutamate. 1[L1] and 2[L2] with secondary nitrogens in this position present significantly larger interactions than 3[L3], which lacks an amino group in the center of the chains. The NMR and modeling studies suggest the important contribution of hydrogen bonding and π-cation interaction to adduct formation.

Lanthanide(III) Complexes of Novel Mixed Carboxylic-Phosphorus Acid Derivatives of Diethylenetriamine: A Step towards More Efficient MRI Contrast Agents

Three novel phosphorus-containing analogues of H5DTPA (DTPA = diethylenetriaminepentaacetate) were synthesised (H6L1, H5L2, H5L3). These compounds have a -CH2-P(O)(OH)-R function (R = OH, Ph, CH2NBn2) attached to the central nitrogen atom of the diethylenetriamine backbone. An NMR study reveals that these ligands bind to lanthanide(III) ions in an octadentate fashion through the three nitrogen atoms, a P-O oxygen atom and four carboxylate oxygen atoms. The complexed ligand occurs in several enantiomeric forms due to the chirality of the central nitrogen atom and the phosphorus atom upon coordination. All lanthanide complexes studied have one coordinated water molecule. The residence times (τM 298) of the coordinated water molecules in the gadolinium(III) complexes of H6L1 and H5L2 are 88 and 92 ns, respectively, which are close to the optimum. This is particularly important upon covalent and noncovalent attachment of these Gd3+ chelates to polymers. The relaxivity of the complexes studied is further enhanced by the presence of at least two water molecules in the second coordination sphere of the Gd3+ ion, which are probably bound to the phosphonate/phosphinate moiety by hydrogen bonds. The complex [Gd(L 3)(H2O)]2- shows strong binding ability to HSA, and the adduct has a relaxivity comparable to MS-325 (40 s-1mM -1 at 40MHz, 37°C) even though it has a less favourable τM value (685 ns). Transmetallation experiments with Zn 2+ indicate that the complexes have a kinetic stability that is comparable to-or better than-those of [Gd(dtpa)(H2O)]2- and [Gd(dtpa-bma)(H2O)].

N-Benzyloxycarbonylaziridine in the Syntheses of 2-Aminoethyl Armed Lariats and Selectively N-Protected Polyazacrown Ethers

The 15- and 18-membered mono- and bi-bracchial N-aminoethylene armed lariats 6, 7 and 8 have been synthesized by alkylations of parent azacrowns using N-benzyloxycarbonylaziridine 2 and subsequent removal of Z-protecting groups by catalytic hydrogenolysis

1-substituted-1,4,7-triscarboxymethyl-1,4,7,10-tetraazacyclododecane and analogs

Metal-chelating liquids having the formula STR1 wherein Y is oxygen or STR2 R1 is hydrogen, alkyl, arylalkyl aryl, alkoxy, hydroxyalkyl STR3 wherein G is STR4

Doubly and Triply Bridged Polyoxapolyazaheterophanes Derived from 2,4,6-Trichloro-s-triazine

Doubly and triply bridged polyoxapolyazaheterophanes (1, 2) have been synthesized from 2,4,6-trichloro-s-triazine by using the different reactivity of the three chlorine atoms toward neutral nucleophiles.Introduction of alkyl groups and/or of heteroatoms in the bridging chains makes these systems soluble in organic solvents.Triazinophanes 1h and 2b, with NH groups in the bridging chains, may be used as phase-transfer catalysts in nucleophilic aliphatic substitutions. 13C NMR spectra indicate that molecules 1 and 2 either exists in a single nonsymmetric conformation up to about room temperature or, more likely, that there are two or more differently populated conformations separated by a high interconversion barrier.