23538-88-7

Upstream product

• 136918-14-4 phthalimide 
• 101-32-6 N-benzyl-diethanolamine 
• 63563-83-7 bis(phthalimidylethyl)amine 
• 100-39-0 benzyl bromide 
• 85-44-9 phthalic anhydride 
• 574-98-1 2-(2-bromoethyl)isoindoline-1,3-dione 
• 100-46-9 benzylamine 

Downstream Products

• 23539-10-8 N¹-(2-aminoethyl)-N1-benzylethane-1,2-diamine 
• 91817-11-7 N-Benzyl-N'-butyl-N-(2-butylamino-ethyl)-ethane-1,2-diamine 
• 91817-09-3 3-Benzyl-N,N'-dibutanoyl-3-aza-1,5-pentanediamine 
• 91817-13-9 N-Benzyl-N'-butyl-N-{2-[butyl-(4,6-dichloro-[1,3,5]triazin-2-yl)-amino]-ethyl}-N'-(4,6-dichloro-[1,3,5]triazin-2-yl)-ethane-1,2-diamine 
• 91817-03-7 5,17-Dibenzyl-2,8,14,20-tetrabutyl-11,23-dichloro-2,5,8,10,12,14,17,20,22,24,25,26-dodecaaza-tricyclo[19.3.1.1^9,13]hexacosa-1⁽²⁵⁾,9,11,13⁽²⁶⁾,21,23-hexaene 
• 47090-93-7 Benzyl-bis-(2-guanidino-ethyl)-amin 

Relevant academic research and scientific papers

Artemisinin derivative and intermediate, and preparation methods and applications thereof

The invention discloses an artemisinin derivative with a structure represented by a general formula (I), and a preparation method of the artemisinin derivative and application of the artemisinin derivative in preparation of antimalarial drugs, and further discloses an intermediate for preparing the artemisinin derivative and preparation of the intermediate.

New N-substituted polyamines. Synthesis, characterization and crystal and molecular structure of 2-[{C6H4(CO)2NCH 2CH2}2NCH2]C6H 4Br

New branched polyamines starting from diethylenetriamine, i.e. (Me 2NCH2CH2)2NCH2C 6H5 (9) and 2-[(Me2NCH2CH 2)2NCH2]C6H4X [X = Cl (10), Br (11)], were prepared by a multi-step procedure. Both the branched polyamines and the corresponding intermediates were characterized by multinuclear NMR spectroscopy in solution. The crystal and molecular structure of the intermediate 2-[{C6H4(CO)2NCH 2CH2}2NCH2]C6H 4Br (5) was established by single-crystal X-ray diffraction.

New 1H-Pyrazole-Containing Polyamine Receptors Able to Complex L-Glutamate in Water at Physiological pH Values

The interaction of the pyrazole-containing macrocyclic receptors 3,6,9,12,13,16,19,22,25,26-decaazatricyclo-[22.2.1.1 11,14]-octacosa-1(27),11,14(28),24-tetraene 1[L1], 13,26-dibenzyl-3,6,9,12,13,16,19,22,25,26-decaazatricyclo-[22.2.1.1 11,14]-octacosa-1(27),11,14(28),24-tetraene 2[L2], 3,9,12,13,16,22,25,26-octaazatricyclo-[22.2.1.1 11,14]-octacosa-1(27),11,14(28),24-tetraene 3[L3], 6,19-dibenzyl-3,6,9,12,13,16,19,22,25,26-decaazatricyclo-[22.2.1.1 11,14]-octacosa-1(27),11,14,(28),24-tetraene 4[L4], 6,19-diphenethyl-3,6,9,12,13,16,19,22,25,26-decaazatricyclo-[22.2.1.1 11,14]-octacosa-1(27),11,14(28),24-tetraene 5[L5], and 6,19-dioctyl-3,6,9,12,13,16,19,22,25,26-decaazatricyclo-[22.2.1.1 11,14]-octacosa-1(27),11,14(28),24-tetraene 6[L6] with L-glutamate in aqueous solution has been studied by potentiometric techniques. The synthesis of receptors 3-6[L3-L6] is described for the first time. The potentiometric results show that 4[L4] containing benzyl groups in the central nitrogens of the polyamine side chains is the receptor displaying the larger interaction at pH 7.4 (Keff = 2.04 × 104). The presence of phenethyl 5[L5] or octyl groups 6[L6] instead of benzyl groups 4[L4] in the central nitrogens of the chains produces a drastic decrease in the stability [Keff = 3.51 × 102 (5), Keff = 3.64 × 102 (6)]. The studies show the relevance of the central polyaminic nitrogen in the interaction with glutamate. 1[L1] and 2[L2] with secondary nitrogens in this position present significantly larger interactions than 3[L3], which lacks an amino group in the center of the chains. The NMR and modeling studies suggest the important contribution of hydrogen bonding and π-cation interaction to adduct formation.

POLYAZACYCLIC COMPOUNDS. PART I. SYNTHESIS OF ARYLSULFONYL DERIVATIVES OF 1,4,7,10-TETRAAZACYCLODODECANE AND 1-OXA-4,7,10-TRIAZACYCLODODECANE SUBSTITUTED AT REQUIRED NITROGEN ATOMS

A method of preparation of new polyazamacrocyclic compounds substituted at required nitrogen atoms is given based on the example of synthesis of the title derivatives.The method consists in the cyclocondensation of substrates, of which at least one has a tertiary amino group present in the macrocyclic compound.

Doubly and Triply Bridged Polyoxapolyazaheterophanes Derived from 2,4,6-Trichloro-s-triazine

Doubly and triply bridged polyoxapolyazaheterophanes (1, 2) have been synthesized from 2,4,6-trichloro-s-triazine by using the different reactivity of the three chlorine atoms toward neutral nucleophiles.Introduction of alkyl groups and/or of heteroatoms in the bridging chains makes these systems soluble in organic solvents.Triazinophanes 1h and 2b, with NH groups in the bridging chains, may be used as phase-transfer catalysts in nucleophilic aliphatic substitutions. 13C NMR spectra indicate that molecules 1 and 2 either exists in a single nonsymmetric conformation up to about room temperature or, more likely, that there are two or more differently populated conformations separated by a high interconversion barrier.