235426-31-0

Basic information

• Product Name: 2-BROMO-1,5-DIMETHYL-1H-IMIDAZOLE
• Synonyms: 2-BROMO-1,5-DIMETHYL-1H-IMIDAZOLE;1H-IMidazole,2-broMo-1,5-diMethyl;2-Bromo-1,5-dimethylimidazole
• CAS NO: 235426-31-0
• Molecular Formula: C₅H₇BrN₂
• Molecular Weight: 175.03
• Product Categories: blocks;Bromides;Imidazoles
• Mol File: 235426-31-0.mol
• Article Data: 3

Chemical Properties

• Melting Point: 40-42
• Boiling Point: 253.6 °C at 760 mmHg
• Flash Point: 107.1 °C
• Appearance: /
• Density: 1.58 g/cm³
• Vapor Pressure: 0.0181mmHg at 25°C
• Refractive Index: 1.589
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 4.17±0.25(Predicted)
• CAS DataBase Reference: 2-BROMO-1,5-DIMETHYL-1H-IMIDAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-BROMO-1,5-DIMETHYL-1H-IMIDAZOLE(235426-31-0)
• EPA Substance Registry System: 2-BROMO-1,5-DIMETHYL-1H-IMIDAZOLE(235426-31-0)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• Hazardous Substances Data: 235426-31-0(Hazardous Substances Data)

Usage

General Description

2-Bromo-1,5-dimethyl-1H-imidazole is a chemical compound with the molecular formula C5H6BrN2. It is a brominated derivative of imidazole, which is a five-membered heterocyclic ring containing two nitrogen atoms. 2-BROMO-1,5-DIMETHYL-1H-IMIDAZOLE is commonly used in organic synthesis and pharmaceutical research due to its versatile reactivity and potential applications in drug development. It is also utilized as an intermediate in the synthesis of various pharmaceutical compounds and agrochemicals. Additionally, 2-Bromo-1,5-dimethyl-1H-imidazole has been studied for its biological activity and is known to exhibit antiparasitic and antimicrobial properties, making it a promising candidate for the development of new therapeutic agents.

InChI:InChI=1/C5H7BrN2/c1-4-3-7-5(6)8(4)2/h3H,1-2H3

Upstream product

• 23328-88-3 2-bromo-5-methyl-1H-imidazole 
• 74-88-4 methyl iodide 
• 333-27-7 methyl trifluoromethanesulfonate 
• 10447-93-5 1,2-dimethylimidazole 

Downstream Products

• 1128191-66-1 N-[3-(1,5-dimethylimidazol-2-yl)-4-methyl-phenyl]-2-methyl-6-(trifluoromethyl)pyridine-3-carboxamide 
• 1128191-82-1 4-chloro-3-(1,5-dimethylimidazol-2-yl)aniline 
• 1128191-07-0 N-[4-chloro-3-(1,5-dimethylimidazol-2-yl)phenyl]-2-methyl-6-(trifluoromethyl)pyridine-3-carboxamide 

Relevant articles and documents

MACROCYCLIC AZOLOPYRIDINE DERIVATIVES AS EED AND PRC2 MODULATORS

The invention relates to modulators of Embryonic Ectoderm Development (EED) and/or Polycomb Repressive Complex 2 (PRC2) useful in the treatment of disorders and diseases associated with EEC and PRC2, being macrocyclic azolopyridine derivatives and compositions thereof of Formula (I), or a pharmaceutically acceptable salt, prodrug, solvate, hydrate, enantiomer, isomer, or tautomer thereof, wherein X1, X2, X3, A1, A2, Y, R1, R2, R3, and R4 are as described herein.

Reaction of imidazoles with cyanogen bromide: Cyanation at N 1 or bromination at C 2?

The reaction in acetonitrile solution of a number of imidazoles (1H-, 1-methyl-, 2-methyl-, 4-methyl-, 1,2-, 1,4- and 1,5-dimethyl-, 1-ethyl-, 1-benzyl- and 1-butyl-imidazole) and imidazole complexes ([Co(NH3)5(imH)](ClO4)3, [Co(NH3)5(im)] (ClO4)2 and [Co(NH3)5(1-Meim)] (ClO4)3) with BrCN has been studied. Those imidazoles bearing an N-alkyl substituent and having a hydrogen at C2 react to give the 2-bromo products, while the N-H imidazoles react to give W-cyano derivatives. The product(s) from the reaction of 1,2-dimethylimidazole with BrCN could not be characterized. Of the complexes, only [Co(NH3)5(im)] (ClO4)2 reacts, giving the 2-bromo product. Our observations suggest a lone pair on a ring nitrogen atom is necessary for an imidazole to react with BrCN, and a possible mechanism is suggested. The X-ray structure of 2-methylimidazole-1-carbonitrile is reported. Crystal data (-143°C) for C5H5N3: monoclinic, P21/c, a 10.201(5), b 7.110(3), c 7.227(3) A, β 100.47(2)°, V 515.4(4) A3, Z 4, dcalcd 1-380 g cm-3. Refinement of the structure converged with R1 0.0444 for 1183 reflections with Fo > 4F(Fo) and ωR2 0.1259 for all 1278 data.