23576-79-6

Basic information

• Product Name: 4-(propan-2-ylamino)phenol
• Synonyms: Phenol, 4-[(1-methylethyl)amino]-; p-Hydroxyphenylisopropylamine
• CAS NO: 23576-79-6
• Molecular Formula: C₉H₁₃NO
• Molecular Weight: 151.2056
• Mol File: 23576-79-6.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 280.7°C at 760 mmHg
• Flash Point: 128.1°C
• Density: 1.074g/cm³
• Vapor Pressure: 0.0022mmHg at 25°C
• Refractive Index: 1.582
• CAS DataBase Reference: 4-(propan-2-ylamino)phenol(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(propan-2-ylamino)phenol(23576-79-6)
• EPA Substance Registry System: 4-(propan-2-ylamino)phenol(23576-79-6)

Safety Data

• Hazardous Substances Data: 23576-79-6(Hazardous Substances Data)

Upstream product

• 100-02-7 4-nitro-phenol 
• 67-64-1 acetone 
• 104-91-6 p-nitrosophenol 
• 637-62-7 p-benzoquinone oxime 
• 123-30-8 4-amino-phenol 
• 33709-30-7 4-hydroxyphenyl-N,N-dimethylimide 

Downstream Products

• 1613063-63-0 2-cyano-N-(4-hydroxyphenyl)-N-isopropylacetamide 
• 91457-26-0 N-isopropyl-N-(4-hydroxyphenyl)-acetamide 
• 99362-45-5 4-(Isopropyl-nitroso-amino)-phenol 

Relevant articles and documents

Versatile synthesis of 4-spiro-β-lactam-3-carbonitriles via the intramolecular nucleophilic cyclization of N-(p-hydroxyphenyl)cyanoacetamides

A series of 4-spiro-cyclohexadienonyl-β-lactam-3-carbonitriles, 2,7-dioxo-1-azaspiro[3.5]nona-5,8-diene-3-carbonitriles, was synthesized in satisfactory to excellent yields via the intramolecular nucleophilic cyclization of N-(p-hydroxyphenyl)cyanoacetamides with iodobenzene diacetate (IBD) as oxidant and potassium hydroxide as base. Acetic 4-spiro-cyclohexadienonyl- β-lactam-3-carbimidic anhydrides were obtained when organic base triethylamine was applied instead of potassium hydroxide. The mechanisms of the intramolecular nucleophilic cyclization and formation of acetic β-lactam-3-carbimidic anhydrides were proposed. The cyclization is a sequence of nucleophilic ipso addition and oxidative dearomatization. The formation of acetic carbimidic anhydrides is an acid-catalyzed acetate addition to the nitriles.