235786-14-8

Basic information

• Product Name: 1-(4S-Benzyl-2-oxo-oxazolidin-3-yl)-2R-butyl-butane-1,3-dione
• Synonyms: 1-(4S-Benzyl-2-oxo-oxazolidin-3-yl)-2R-butyl-butane-1,3-dione
• CAS NO: 235786-14-8
• Molecular Weight: 317.385
• Mol File: 235786-14-8.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 1-(4S-Benzyl-2-oxo-oxazolidin-3-yl)-2R-butyl-butane-1,3-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4S-Benzyl-2-oxo-oxazolidin-3-yl)-2R-butyl-butane-1,3-dione(235786-14-8)
• EPA Substance Registry System: 1-(4S-Benzyl-2-oxo-oxazolidin-3-yl)-2R-butyl-butane-1,3-dione(235786-14-8)

Safety Data

• Hazardous Substances Data: 235786-14-8(Hazardous Substances Data)

Upstream product

• 142-61-0 Hexanoyl chloride 
• 75-36-5 acetyl chloride 
• 90719-32-7 (S)-4-Benzyl-2-oxazolidinone 
• 143965-32-6 (4S)-3-hexanoyl-4-(phenylmethyl)-1,3-oxazolidin-2-one 

Downstream Products

• 235786-20-6 N-[2-(4-benzyl-2-oxo-oxazolidine-3-carbonyl)-1-methyl-hexyl]-N-benzyloxy-formamide 
• 235786-19-3 (S)-4-Benzyl-3-[(R)-2-(1-benzyloxyamino-ethyl)-hexanoyl]-oxazolidin-2-one 
• 235786-25-1 (R)-2-[1-(Benzyloxy-formyl-amino)-ethyl]-hexanoic acid ((S)-1-dimethylcarbamoyl-2,2-dimethyl-propyl)-amide 
• 235786-21-7 (R)-2-[1-(Benzyloxy-formyl-amino)-ethyl]-hexanoic acid 
• 235786-16-0 1-(4S-Benzyl-2-oxo-oxazolidin-3-yl)-2R-butyl-butane-1,3-dione 3-(O-benzyloxime) 

Relevant articles and documents

Structure-activity relationships of the peptide deformylase inhibitor BB-3497: Modification of the methylene spacer and the P1′ side chain

Structural modifications to the peptide deformylase inhibitor BB-3497 are described. In this paper, we describe the initial SAR around this lead for modifications to the methylene spacer and the P1′ side chain. Enzyme inhibition and antibacterial activity data revealed that the optimum distance between the N-formyl hydroxylamine metal binding group and the P1′ side chain is one unsubstituted methylene unit. Additionally, lipophilic P1′ side chains that closely mimic the methionine residue in the substrate provided compounds with the best microbiological profile.