23596-25-0

Usage

Uses

Used in Pharmaceutical Industry:
6-Chloro-2,3-dihydro-1H-pyrrolo[3,2-c]pyridine is used as a selective agonist for metabotropic glutamate receptors mGlu2/3 for its potential therapeutic effects on central nervous system disorders.
Used in Treatment of Schizophrenia:
6-Chloro-2,3-dihydro-1H-pyrrolo[3,2-c]pyridine is used as a potential treatment for schizophrenia, aiming to alleviate symptoms by modulating glutamate levels in the brain.
Used in Treatment of Anxiety:
6-Chloro-2,3-dihydro-1H-pyrrolo[3,2-c]pyridine is used as a potential anxiolytic agent, helping to reduce anxiety symptoms through its action on glutamate neurotransmission.
Used in Treatment of Depression:
6-Chloro-2,3-dihydro-1H-pyrrolo[3,2-c]pyridine is used as a potential antidepressant, potentially improving mood and depressive symptoms by modulating glutamate neurotransmission.
Used in Anti-Inflammatory Applications:
6-Chloro-2,3-dihydro-1H-pyrrolo[3,2-c]pyridine is used as an anti-inflammatory agent, potentially reducing inflammation in the brain and other tissues.
Used in Neurodegenerative Disease Treatment:
6-Chloro-2,3-dihydro-1H-pyrrolo[3,2-c]pyridine is used as a potential treatment for neurodegenerative diseases, potentially slowing disease progression by modulating glutamate neurotransmission and providing neuroprotection.

InChI:InChI=1/C7H7ClN2/c8-7-3-6-5(4-10-7)1-2-9-6/h3-4,9H,1-2H2

Upstream product

• 66751-32-4 1-benzyl-6-chloro-7-cyano-5-azaindoline 
• 800402-12-4 2-chloro-4-amino-5-iodopyridine 
• 14432-12-3 4-Amino-2-chloropyridine 
• 74976-31-1 6-chloro-1H-pyrrolo[3,2-c]pyridine 
• 66751-33-5 6-hydroxy-5-azaindoline 
• 68-12-2 N,N-dimethyl-formamide 

Downstream Products

• 24603-30-3 6-methoxy-5-azaindoline 
• 74976-31-1 6-chloro-1H-pyrrolo[3,2-c]pyridine 
• 1649470-12-1 tert-butyl 6-chloro-2,3-dihydro-1H-pyrrolo[3,2-c]pyridine-1-carboxylate 
• 80862-08-4 6-methoxy-5-azaindole 
• 74976-33-3 3-(4-methyl-1-piperazinylmethyl)-6-chloro-5-azaindole 

Relevant academic research and scientific papers

RORγ MODULATORS

The invention provides an RORγ receptor agonist comprising a compound of formula (I), wherein the variables are as defined herein. These compounds are analogous to known RORγ receptor antagonists. The invention further provides a method of activating -the nuclear receptor RORγ, comprising -contacting the RORγ with an effective amount or concentration of a compound of the invention; and a method of treating cancer in a patient, comprising administering to the patient an effective dose of a compound of the invention.

TYK2 INHIBITORS AND USES THEREOF

The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of TYK2, and the treatment of TYK2-mediated disorders.

Fragment-Based Drug Discovery Targeting Inhibitor of Apoptosis Proteins: Discovery of a Non-Alanine Lead Series with Dual Activity Against cIAP1 and XIAP

(Figure Presented) Inhibitor of apoptosis proteins (IAPs) are important regulators of apoptosis and pro-survival signaling pathways whose deregulation is often associated with tumor genesis and tumor growth. IAPs have been proposed as targets for anticanc

BICYCLIC HETEROCYCLE COMPOUNDS AND THEIR USES IN THERAPY

The invention relates to bicyclic heterocycle compounds of formula (I): or tautomeric or stereochemically isomeric forms, N-oxides, pharmaceutically acceptable salts or the solvates thereof; wherein R1, R2a, R2b, R3a, R3b, R5, R6, R7, R8, R9, p and E are as defined herein; to pharmaceutical compositions comprising said compounds and to the use of said compounds in the treatment of diseases, e.g. cancer.

PPAR ACTIVE COMPOUNDS

Compounds are described that are active on PPARs, including pan-active compounds. Also described are methods for developing or identifying compounds having a desired selectivity profile.

PPAR active compounds

Compounds are described that are active on PPARs, including pan-active compounds. Also described are methods for developing or identifying compounds having a desired selectivity profile.

Azaindole derivatives. 61. Electrophilic substitution reactions in 1-benzyl-6-methoxy-7-cyano-5-azaindole and 6-oxo-5-azaindoline

The electrophilic substitution reactions (nitration, bromination, acylation, and the Mannich and Vilsmeier reactions) of 1-benzyl-6-methoxy-7-cyano-5-azaindole and the nitration and Vilsmeier reaction of 6-hydroxy-5-azaindoline were studied.

AZAINDOLE DERIVATIVES. 59. SYNTHESIS AND CHEMICAL PROPERTIES OF 1-BENZYL-4-DIMETHYLAMINO-6-CHLORO-7-CYANO-5-AZAINDOLINE

The condensation of 1-benzyl-2-cyanocarbamoylmethylene-pyrrolidine with tetramethylurea diethylacetal and subsequent cyclization gave 1-benzyl-4-dimethylamino-6-chloro-7-cyano-5-azaindoline, for which nucleophilic substitution and dehydrogenation reaction