23600-63-7

Usage

Preparation

Preparation by reaction of dimethyl sulfate with 4-bromo-2-hydroxypropiophenone.

Upstream product

• 17764-92-0 1-(4-bromo-2-hydroxyphenyl)-propan-1-one 
• 77-78-1 dimethyl sulfate 
• 72135-36-5 4-bromo-2-methoxybenzoic acid 
• 2386-64-3 ethylmagnesium chloride 
• 23689-33-0 3-bromophenyl propionic acid 
• 591-20-8 3-Bromophenol 

Relevant academic research and scientific papers

PHENYL SUBSTITUTED PYRAZOLES AS MODULATORS OF RORgT

The present invention comprises compounds of Formula I. wherein: R1, R3, R4, R5, R6, R7, R8, and Q are defined in the specification. The invention also comprises a method of treating or ameliorating a ROR-γ-t mediated syndrome, disorder or disease, including wherein the syndrome, disorder or disease is selected from the group consisting of rheumatoid arthritis, psoriatic arthritis, and psoriasis. The invention also comprises a method of modulating RORγt activity in a mammal by administration of a therapeutically effective amount of at least one compound of Formula I.

SUBSTITUTED IMIDAZOLONE DERIVATIVES, PREPARATIONS AND USES

The present invention relates to polysubstituted imidazolone derivatives, to the pharmaceutical compositions comprising them and to the therapeutic uses thereof in the human and animal health fields. The present invention also relates to a process for preparing these derivatives.