23689-33-0

Basic information

• Product Name: 3-bromophenyl propionic acid
• Synonyms: 3-bromophenyl propionic acid
• CAS NO: 23689-33-0
• Molecular Weight: 229.073
• Mol File: 23689-33-0.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 3-bromophenyl propionic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 3-bromophenyl propionic acid(23689-33-0)
• EPA Substance Registry System: 3-bromophenyl propionic acid(23689-33-0)

Safety Data

• Hazardous Substances Data: 23689-33-0(Hazardous Substances Data)

Upstream product

• 591-20-8 3-Bromophenol 
• 79-03-8 propionyl chloride 
• 802294-64-0 propionic acid 

Downstream Products

• 1375998-97-2 1-(2-allyloxy-4-bromo-phenyl)propan-1-one 
• 1375999-01-1 1-(3-allyl-4-bromo-2-hydroxyphenyl)propan-1-one 
• 151583-29-8 methyl 3-(3'-bromophenyl)-propionate 
• 17764-92-0 1-(4-bromo-2-hydroxyphenyl)-propan-1-one 
• 18430-73-4 3-Brom-4-propionyl-phenol 
• 23600-68-2 2,3,4-Tribrom-6-propionyl-anisol 
• 23689-25-0 2,3,6-Tribrom-4-propionyl-anisol 
• 17765-09-2 2,3,6-Tribrom-4-propionyl-phenol 
• 17765-22-9 2,3,4-Dibrom-6-propionyl-phenol 
• 23600-63-7 1-(4-bromo-2-methoxyphenyl)propan-1-one 
• 24876-04-8 1-(2-bromo-4-methoxy-phenyl)-propan-1-one 
• 23689-26-1 2,3,6-Tribrom-4-<1-hydroxy-propyl>-anisol 
• 23600-70-6 2,3,4-Tribrom-6-<1-hydroxy-propyl>-anisol 
• 23600-60-4 3-Brom-4-<1-hydroxy-propyl>-anisol 

Relevant articles and documents

How much does the hybridization of a carbon atom affect the transmission of the substituent effect on the chemical shift?

1H and 13C NMR spectra of aryl esters of propionic acid, acrylic acid, and propiolic acid were systematically examined to find out the substituent effect on the chemical shift. The values of the chemical shift of the carbonyl carbon showed an inverse correlation with the Hammett ?3 values, and the magnitude of the slope was the largest with the propiolates. The ?± carbons of acrylates and propiolates also showed an inverse correlation with much smaller values of the slopes than those of the carbonyl carbons; but those of the propionates showed absolutely no correlation. However, the ?2 carbons of acrylates and propiolates showed normal correlation with larger values of the slopes. The signs and the magnitudes of the slopes may be understood by the transmission of the substituent electronic effect through bonds as well as through space. The propiolyloxy group also showed a significantly large effect on the 13C chemical shift values of the benzene ring.

VLA-4 inhibitor compounds

Compounds that selectively inhibit the binding of ligands to alpha4beta1 integrin (VLA-4) and methods for their preparation are disclosed. In one embodiment, compounds of the invention are represented by Formula I: As selective inhibitors of VLA-4 mediated cell adhesion, compounds of the present invention are useful in the treatment of conditions associated with such adhesion, including, but not limited to, such conditions as inflammatory and autoimmune responses, diabetes, asthma, psoriasis, inflammatory bowel disease, transplantation rejection, and tumor metastasis. Also disclosed are pharmaceutical compositions, methods of inhibiting VLA-4 mediated cell adhesion and methods of treating conditions associated with LA-4 mediated cell adhesion, which involve compounds of Formula I.