17764-92-0

Basic information

• Product Name: 1-(4-BROMO-2-HYDROXYPHENYL)-1-PROPANONE
• Synonyms: 1-(4-BROMO-2-HYDROXYPHENYL)-1-PROPANONE;Propiophenone, 4'-bromo-2'-hydroxy-
• CAS NO: 17764-92-0
• Molecular Formula: C₉H₉BrO₂
• Molecular Weight: 229.07
• Mol File: 17764-92-0.mol
• Article Data: 6

Chemical Properties

• Melting Point: 48-49°C
• Boiling Point: 301.5°Cat760mmHg
• Flash Point: 136.1°C
• Appearance: /
• Density: 1.506g/cm³
• Vapor Pressure: 0.000588mmHg at 25°C
• Refractive Index: 1.578
• CAS DataBase Reference: 1-(4-BROMO-2-HYDROXYPHENYL)-1-PROPANONE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-BROMO-2-HYDROXYPHENYL)-1-PROPANONE(17764-92-0)
• EPA Substance Registry System: 1-(4-BROMO-2-HYDROXYPHENYL)-1-PROPANONE(17764-92-0)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 17764-92-0(Hazardous Substances Data)

Usage

Uses

1-(4-Bromo-2-hydroxyphenyl)-1-propanone is a useful compound for preparation of indazoles.

Preparation

Preparation by Friedel–Crafts acylation of m-bromophenol with propionyl chloride in the presence of aluminium chloride in refluxing ethylene dichloride for 2 h (78%)Also obtained by Fries rearrangement of 3-bromophenyl propionate in the presence of aluminium chloride at 50° for 3 h (47%).

InChI:InChI=1/C9H9BrO2/c1-2-8(11)7-4-3-6(10)5-9(7)12/h3-5,12H,2H2,1H3

Upstream product

• 591-20-8 3-Bromophenol 
• 79-03-8 propionyl chloride 
• 23689-33-0 3-bromophenyl propionic acid 

Downstream Products

• 1607025-27-3 methyl 3-ethylbenzo[d]isoxazole-6-carboxylate 
• 1607025-26-2 methyl 3-hydroxy-4-(1-iminopropyl)benzoate 
• 1375998-97-2 1-(2-allyloxy-4-bromo-phenyl)propan-1-one 
• 1375999-01-1 1-(3-allyl-4-bromo-2-hydroxyphenyl)propan-1-one 
• 23600-68-2 2,3,4-Tribrom-6-propionyl-anisol 
• 23600-70-6 2,3,4-Tribrom-6-<1-hydroxy-propyl>-anisol 
• 23600-65-9 3-Brom-6-<1-hydroxy-propyl>-anisol 
• 215815-09-1 6-bromo-1-methyl-3-ethyl-1H-indazole 
• 215815-08-0 5-bromo-2-propionylphenyl methanesulfonate 
• 23600-63-7 1-(4-bromo-2-methoxyphenyl)propan-1-one 

Relevant articles and documents

The synthesis of a selective PDE4/TNFα inhibitor

Two syntheses of cis-4-cyano-4-(1-cyclohexyl-3-ethyl-1H-indazol-6-yl)cyclohexanecarboxylic acid (1), a selective PDE4/TNFα inhibitor are described. The first synthesis relied on a solvolysis of a tertiary benzylic alcohol to the nitrile using T

HETEROCYCLIC COMPOUNDS FOR THE INHIBITION OF PASK

Disclosed herein are new heterocyclic compounds and compositions and their application as pharmaceuticals for the treatment of disease. Methods of inhibiting PAS Kinase (PASK) activity in a human or animal subject are also provided for the treatment of diseases such as diabetes mellitus.

ARYLSULFONAMIDE-BASED MATRIX METALLOPROTEASE INHIBITORS

The present invention provides a compound of formula (I):said compound is inhibitor of MMP-2, and/or MMP-8, and/or MMP-9, and/or MMP-12 and/or MMP-13, and thus can be employed for the treatment of a disorder or disease characterized by abnormal activity of MMP-2, and/or MMP-8, and/or MMP-9, and/or MMP-12 and/or MMP- 13. Accordingly, the compound of formula (I) can be used in treatment of disorders or diseases mediated by MMP-2, and/or MMP-8, and/or MMP-9, and/or MMP-12, and/or MMP- 13. Finally, the present invention also provides a pharmaceutical composition.