23608-88-0

Upstream product

• 5394-18-3 2-(4-bromobutyl)isoindoline-1,3-dione 
• 103-49-1 dibenzylamine 
• 136918-14-4 phthalimide 

Downstream Products

• 768369-96-6 dec-9-enoic acid [3-(2-allyl-piperidin-1-yl)-propyl]-(4-dibenzylamino-butyl)-amide 
• 768370-04-3 8-(4-dibenzylamino-butyl)-octadecahydro-4a,8-diaza-benzocycloheptadecen-9-one 
• 768369-95-5 8-(4-dibenzylamino-butyl)-1,3,4,5,6,7,8,10,11,12,13,14,15,16,19,19a-hexadecahydro-2H-4a,8-diaza-benzocycloheptadecen-9-one 
• 768369-99-9 1-{3-[4-(dibenzylaminobutyl)amino]propionyl}-2-allylpiperidine 
• 768370-00-9 1-{3-[4-(dibenzylaminobutyl)amino]propyl}-2-allylpiperidine 
• 29867-07-0 N₁,N₄-dibenzyl-1,4-diaminobutane 

Relevant academic research and scientific papers

Reversal agent and linker variants of reversed chloroquines: Activities against Plasmodium falciparum

We have shown that "reversed chloroquine molecules" constructed from chloroquine-like and resistance "reversal-agent"-like cores can be powerful drugs against malaria (J. Med. Chem. 2006, 49, 5623-5625). Several reversed chloroquines are now presented that probe parameters governing the activities against chloroquine-resistant and chloroquine-sensitive malaria strains. The design is tolerant to linker and reversal agent changes, but a piperazinyl group adjacent to the quinoline, at least for the group of compounds studied here, may be detrimental. 2009 American Chemical Society.

Efficient syntheses of oncinotine and neooncinotine

We have synthesized two natural alkaloids, oncinotine (1) and neooncinotine (2), by means of efficient ring-closing metathesis (RCM) reactions. The required dienes for RCM were assembled from three basic components: 2-allylpiperidine (5), 9-decenoic acid (6), and diamines 7. We developed two different methods to achieve the linkage: the Michael addition of acrylamide and two amidations of succinic anhydride. The Grubbs catalyst was used to form the 17- and 18-membered lactams in 50% and 68% yields, respectively.