768369-95-5

Upstream product

• 29867-07-0 N₁,N₄-dibenzyl-1,4-diaminobutane 
• 116902-88-6 9-decenoic acid chloride 
• 14436-32-9 dec-9-enoic acid 
• 768369-98-8 N-acryloyl-2-allylpiperidine 
• 768369-96-6 dec-9-enoic acid [3-(2-allyl-piperidin-1-yl)-propyl]-(4-dibenzylamino-butyl)-amide 
• 768369-99-9 1-{3-[4-(dibenzylaminobutyl)amino]propionyl}-2-allylpiperidine 
• 768370-00-9 1-{3-[4-(dibenzylaminobutyl)amino]propyl}-2-allylpiperidine 
• 23608-88-0 2-(4-dibenzylaminobutyl)-isoindole-1,3-dione 

Relevant academic research and scientific papers

Efficient syntheses of oncinotine and neooncinotine

We have synthesized two natural alkaloids, oncinotine (1) and neooncinotine (2), by means of efficient ring-closing metathesis (RCM) reactions. The required dienes for RCM were assembled from three basic components: 2-allylpiperidine (5), 9-decenoic acid (6), and diamines 7. We developed two different methods to achieve the linkage: the Michael addition of acrylamide and two amidations of succinic anhydride. The Grubbs catalyst was used to form the 17- and 18-membered lactams in 50% and 68% yields, respectively.