29867-07-0

Basic information

• Product Name: N₁,N₄-dibenzyl-1,4-diaminobutane
• Synonyms: N₁,N₄-dibenzyl-1,4-diaminobutane
• CAS NO: 29867-07-0
• Molecular Weight: 268.402
• Mol File: 29867-07-0.mol

Chemical Properties

• CAS DataBase Reference: N₁,N₄-dibenzyl-1,4-diaminobutane(CAS DataBase Reference)
• NIST Chemistry Reference: N₁,N₄-dibenzyl-1,4-diaminobutane(29867-07-0)
• EPA Substance Registry System: N₁,N₄-dibenzyl-1,4-diaminobutane(29867-07-0)

Safety Data

• Hazardous Substances Data: 29867-07-0(Hazardous Substances Data)

Upstream product

• 103-49-1 dibenzylamine 
• 540755-13-3 C₁₈H₂₀ClNO 
• 1286232-16-3 4-azido-N,N-dibenzylbutyramide 
• 23608-88-0 2-(4-dibenzylaminobutyl)-isoindole-1,3-dione 
• 55096-93-0 4-dibenzylamino-butyronitrile 

Downstream Products

• 768369-99-9 1-{3-[4-(dibenzylaminobutyl)amino]propionyl}-2-allylpiperidine 
• 768370-00-9 1-{3-[4-(dibenzylaminobutyl)amino]propyl}-2-allylpiperidine 
• 768369-95-5 8-(4-dibenzylamino-butyl)-1,3,4,5,6,7,8,10,11,12,13,14,15,16,19,19a-hexadecahydro-2H-4a,8-diaza-benzocycloheptadecen-9-one 
• 768370-04-3 8-(4-dibenzylamino-butyl)-octadecahydro-4a,8-diaza-benzocycloheptadecen-9-one 
• 768369-96-6 dec-9-enoic acid [3-(2-allyl-piperidin-1-yl)-propyl]-(4-dibenzylamino-butyl)-amide 

Relevant articles and documents

New synthetic routes for N-substituted 1,n-diamines. II. Synthesis of selectively N-substituted tetra- and pentamethylenediamines from ω-alkanoic acid derivatives

A new approach for the synthesis of selectively N-substituted tetra- and pentamethylenediamines 1 (n = 4,5) is described. The method uses N-substituted ω-haloalkanamides 2 as precursors and involves the microwave-promoted conversion into ω-azidocarboxamides 3 and later the reduction of both azido and carboxamide groups with diborane.

Reversal agent and linker variants of reversed chloroquines: Activities against Plasmodium falciparum

We have shown that "reversed chloroquine molecules" constructed from chloroquine-like and resistance "reversal-agent"-like cores can be powerful drugs against malaria (J. Med. Chem. 2006, 49, 5623-5625). Several reversed chloroquines are now presented that probe parameters governing the activities against chloroquine-resistant and chloroquine-sensitive malaria strains. The design is tolerant to linker and reversal agent changes, but a piperazinyl group adjacent to the quinoline, at least for the group of compounds studied here, may be detrimental. 2009 American Chemical Society.

Efficient syntheses of oncinotine and neooncinotine

We have synthesized two natural alkaloids, oncinotine (1) and neooncinotine (2), by means of efficient ring-closing metathesis (RCM) reactions. The required dienes for RCM were assembled from three basic components: 2-allylpiperidine (5), 9-decenoic acid (6), and diamines 7. We developed two different methods to achieve the linkage: the Michael addition of acrylamide and two amidations of succinic anhydride. The Grubbs catalyst was used to form the 17- and 18-membered lactams in 50% and 68% yields, respectively.

Fibrin stabilizing factor inhibitors. 12. 5 dibenzylaminopentylamine and related compounds, a new type of FSF inhibitors

A series of omega dibenzylaminoalkylamines and related compounds have been prepared and tested as inhibitors of fibrin cross linking. This structural type was chosen in an attempt to develop noncompetitive inhibitors of fibrinoligase. By the combination o