86847-64-5

Usage

Uses

Used in Pharmaceutical Industry:
N-(3-FORMYL-2-PYRIDINYL)-2,2-DIMETHYLPROPANAMIDE is used as a reactant for the preparation of disubstituted azaindolines, which are important intermediates in the synthesis of various pharmaceutical compounds. These azaindolines can be further modified to develop new drugs with potential therapeutic applications.
Used in Organic Synthesis:
In the field of organic synthesis, N-(3-FORMYL-2-PYRIDINYL)-2,2-DIMETHYLPROPANAMIDE serves as a versatile reactant for the preparation of a wide range of organic compounds. Its unique structure allows for various chemical reactions, such as condensation, cyclization, and functional group transformations, enabling the synthesis of complex molecules with diverse properties and applications.

InChI:InChI=1/C11H14N2O2/c1-11(2,3)10(15)13-9-8(7-14)5-4-6-12-9/h4-7H,1-3H3,(H,12,13,15)

Upstream product

• 4394-85-8 4-morpholinecarboxaldehyde 
• 86847-59-8 2-(pivaloylamino)pyridine 
• 504-29-0 2-aminopyridine 
• 3282-30-2 pivaloyl chloride 
• 2591-86-8 N-Formylpiperidine 
• 109-72-8 n-butyllithium 
• 68-12-2 N,N-dimethyl-formamide 
• 7521-41-7 2-Aminonicotinaldehyde 

Downstream Products

• 1569-16-0 2-methyl-[1,8]naphthyridine 
• 14903-78-7 2,7-dimethyl-[1,8]naphthyridine 
• 1239164-86-3 ethyl 1-benzyl-2-oxo-1,2-dihydro-1,8-naphthyridine-3-carboxylate 
• 1239164-62-5 1-benzyl-2-oxo-1,2-dihydro-1,8-naphthyridine-3-carboxylic acid chloride 
• 1239164-85-2 1-benzyl-2-oxo-1,2-dihydro-1,8-naphthyridine-3-carboxylic acid 
• 1239164-60-3 3-oxo-1-cyclohexenyl 1-benzyl-2-oxo-1,2-dihydro-1,8-naphthyridine-3-carboxylate 
• 1239164-12-5 1-benzyl-3-(2-hydroxy-6-oxo-1-cyclohexenecarbonyl)-1,8-naphthyridin-2(1H)-one 
• 1239164-56-7 3-oxo-1-cyclohexenyl 1-methyl-2-oxo-1,2-dihydro-1,8-naphthyridin-3-carboxylate 
• 1239164-04-5 3-(2-hydroxy-6-oxo-1-cyclohexenecarbonyl)-1-methyl-1,8-naphthyridin-2(1H)-one 
• 5174-90-3 1,8-naphthyridin-2(1H)-on-3-carboxylic acid ethyl ester 
• 23612-57-9 (2-amino-3-pyridinyl)methanol 
• 7521-41-7 2-Aminonicotinaldehyde 

Relevant academic research and scientific papers

Method for preparing 2-amino-3-hydroxymethylpyridine

The invention discloses a method for preparing 2-amino-3-hydroxymethylpyridine, and belongs to the field of chemical synthesis. 2-aminopyridine and pivaloyl chloride are used as initial reactants to form intermediate product 2-pivalamidopyridine under the action of triethylamine, after hydrogen extraction by use of n-butyllithium, dimethylformamide is added for hydroformylation, and target product2-amino-3-hydroxymethylpyridine can be obtained by reduction with sodium borohydride. Raw materials used in the method are low in cost, and the method is simple in operation, short in synthesis process, mild in reaction conditions, high in yield, and suitable for large-scale industrial production.

Diruthenium complexes with a 1,8-Naphthyridine-based Bis(silyl) supporting ligand: Synthesis and structures of complexes containing RuII2(μ-H)2 and RuI2 cores

We designed a novel naphthyridine-based supporting ligand involving two silyl coordinating moieties at 2,7-positions, t-BuNBSi, for the synthesis of dinuclear metal complexes. Reaction of a ligand precursor t-BuNBSi(H)2 (1) with Ru3(CO)12 gave a di-μ-hydridodiruthenium(II,II) complex (t-BuNBSi)Ru2(μ-H)2(CO)4 (2). Photoirradiation to 2 resulted in the formation of a diruthenium(I,I) complex (t-BuNBSi)Ru2(CO)6 (3). The SiRuRuSi linkage of 2 takes a zigzag arrangement, whereas that of 3 adopts a roughly linear one.

HETEROCYCLIC CGRP RECEPTOR ANTAGONISTS

The present invention is directed to heterocyclic compounds which are antagonists of CGRP receptors and may be useful in the treatment or prevention of diseases in which CGRP is involved, such as migraine. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.

RING-FUSED 2-PYRIDONE DERIVATIVES AND HERBICIDES

Provided are 2-pyridone derivatives which have excellent herbicidal activity and exhibit high safety to useful crops and so on; salts thereof; and herbicides containing same. In more detail, 2-pyridone derivatives represented by general formula [I] or agrochemically acceptable salts thereof, and herbicides containing these compounds are provided. In general formula [I], X1 is an oxygen atom or a sulfur atom; X2, X3, and X4 are to each CH or N(O)m; m is an integer of 0 or 1; R1 is a hydrogen atom, a C1-12 alkyl group, or the like; R2 is a halogen atom, a cyano group, or the like; n is an integer of 0 to 4; R3 is a hydroxyl group, a halogen atom, or the like; A1 is C(R11R12); A2 is C(R13R14) or C═O; A3 is C(R15R16); and R11, R12, R13, R14, R15, and R16 are each independently a hydrogen atom or a C1-6 alkyl group.

CONSTRAINED COMPOUNDS AS CGRP-RECEPTOR ANTAGONISTS

The invention encompasses constrained bicyclic and tricyclic CGRP-receptor antagonists, methods for identifying them, pharmaceutical compositions comprising them, and methods for their use in therapy for treatment of migraine and other headaches, neurogenic vasodilation, neurogenic inflammation, thermal injury, circulatory shock, flushing associated with menopause, airway inflammatory diseases, such as asthma and chronic obstructive pulmonary disease (COPD), and other conditions the treatment of which can be effected by the antagonism of CGRP-receptors.

CGRP antagonists

The present invention encompasses compounds of Formula I which are antagonists of calcitonin gene-related peptide receptors (“CGRP-receptor”), pharmaceutical compositions comprising them, methods for identifying them, methods of treatment using them and t

NOVEL ANTIMALARIA AGENT CONTAINING HETEROCYCLIC COMPOUND

Disclosed is an antimalarial agent containing a compound represented by the formula: [wherein A1 represents a 3-pyridyl group that may have a substituent, a 6-quinolyl group that may have a substituent, or the like; X1 represents a group represented by the formula -C(=O)-NH- or the like; E represents a furyl group, a thienyl group or a phenyl group; with the proviso that A1 may have one to three substituents, and E has one of two substituents] or a salt thereof or hydrates thereof.

Constrained compounds as CGRP-receptor antagonists

The invention encompasses constrained bicyclic and tricyclic CGRP-receptor antagonists, methods for identifying them, pharmaceutical compositions comprising them, and methods for their use in therapy for treatment of migraine and other headaches, neurogenic vasodilation, neurogenic inflammation, thermal injury, circulatory shock, flushing associated with menopause, airway inflammatory diseases, such as asthma and chronic obstructive pulmonary disease (COPD), and other conditions the treatment of which can be effected by the antagonism of CGRP-receptors.

NOVEL ANTIFUNGAL AGENT COMPRISING HETEROCYCLIC COMPOUND

The present invention provides an antifungal agent represented by the formula: [wherein A1 represents a 3-pyridyl group which may have a substituent, a quinolyl group which may have a substituent, or the like; X1 represents a group represented by the formula -NH-C(=O)-, a group represented by the formula -C(=O)-NH-, or the like; E represents a furyl group, a thienyl group, a pyrrolyl group, a phenyl group, a pyridyl group, a tetrazolyl group, a thiazolyl group or a pyrazolyl group; with the proviso that A1 may have 1 to 3 substituents, and E has one or two substituents].

VITRONECTIN RECEPTOR ANTAGONISTS

Compounds of formula (I) are disclosed which are vitronectin receptor antagonists and are useful in the treatment of osteoporosis wherein R is Het- or Ar; R is formula (a) or formula (b); or a pharmaceutically acceptable salt thereof.