86847-64-5

Basic information

• Product Name: N-(3-FORMYL-2-PYRIDINYL)-2,2-DIMETHYLPROPANAMIDE
• Synonyms: N-(3-Formyl-2-pyridinyl)-2,2-dimethylpropanamide ,95%;2-[(2,2-Dimethylpropanoyl)amino]nicotinaldehyde;N-(3-Formyl-2-pyridinyl)-2,2-dimethylpropanamide ,90%;N-(3-Formyl-2-pyridinyl)pivalamide;2-PivalylaMino-Pyridine-3-carboxyaldehyde;N-(3-Formyl-2-pyridinyl)-2,2-dimethylpropanamide 97%;N-(3-FORMYLPYRIDIN-2-YL)-2,2-DIMETHYLPROPANAMIDE;N-(3-FORMYL-PYRIDIN-2-YL)-2,2-DIMETHYL-PROPIONAMIDE
• CAS NO: 86847-64-5
• Molecular Formula: C₁₁H₁₄N₂O₂
• Molecular Weight: 206.24
• Product Categories: Aldehydes;Building Blocks;C10-C12;C11;Carbonyl Compounds;Chemical Synthesis;Heterocyclic Building Blocks;Organic Building Blocks;Pyridine;Pyridines;C9 to C46;Heterocyclic Building Blocks
• Mol File: 86847-64-5.mol
• Article Data: 18

Chemical Properties

• Melting Point: 85-88°C
• Boiling Point: 406.1 °C at 760 mmHg
• Flash Point: 199.4 °C
• Appearance: /
• Density: 1.165 g/cm³
• Vapor Pressure: 8.35E-07mmHg at 25°C
• Refractive Index: 1.584
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Sensitive: Air Sensitive
• CAS DataBase Reference: N-(3-FORMYL-2-PYRIDINYL)-2,2-DIMETHYLPROPANAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: N-(3-FORMYL-2-PYRIDINYL)-2,2-DIMETHYLPROPANAMIDE(86847-64-5)
• EPA Substance Registry System: N-(3-FORMYL-2-PYRIDINYL)-2,2-DIMETHYLPROPANAMIDE(86847-64-5)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38-43
• Safety Statements: 26-36/37
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 86847-64-5(Hazardous Substances Data)

Usage

Chemical Properties

White to yellow solid

Uses

Different sources of media describe the Uses of 86847-64-5 differently. You can refer to the following data:
1. Reactant for:Preparation of disubstituted azaindolines
2. Reactant for:? ;Preparation of disubstituted azaindolines1

InChI:InChI=1/C11H14N2O2/c1-11(2,3)10(15)13-9-8(7-14)5-4-6-12-9/h4-7H,1-3H3,(H,12,13,15)

Upstream product

• 7521-41-7 2-Aminonicotinaldehyde 
• 3282-30-2 pivaloyl chloride 
• 86847-59-8 2-(pivaloylamino)pyridine 
• 109-72-8 n-butyllithium 
• 68-12-2 N,N-dimethyl-formamide 
• 2591-86-8 N-Formylpiperidine 
• 4394-85-8 4-morpholinecarboxaldehyde 
• 504-29-0 2-aminopyridine 

Downstream Products

• 1569-16-0 2-methyl-[1,8]naphthyridine 
• 14903-78-7 2,7-dimethyl-[1,8]naphthyridine 
• 1239164-86-3 ethyl 1-benzyl-2-oxo-1,2-dihydro-1,8-naphthyridine-3-carboxylate 
• 1239164-62-5 1-benzyl-2-oxo-1,2-dihydro-1,8-naphthyridine-3-carboxylic acid chloride 
• 1239164-85-2 1-benzyl-2-oxo-1,2-dihydro-1,8-naphthyridine-3-carboxylic acid 
• 1239164-60-3 3-oxo-1-cyclohexenyl 1-benzyl-2-oxo-1,2-dihydro-1,8-naphthyridine-3-carboxylate 
• 1239164-12-5 1-benzyl-3-(2-hydroxy-6-oxo-1-cyclohexenecarbonyl)-1,8-naphthyridin-2(1H)-one 
• 1239164-56-7 3-oxo-1-cyclohexenyl 1-methyl-2-oxo-1,2-dihydro-1,8-naphthyridin-3-carboxylate 
• 1239164-04-5 3-(2-hydroxy-6-oxo-1-cyclohexenecarbonyl)-1-methyl-1,8-naphthyridin-2(1H)-one 
• 5174-90-3 1,8-naphthyridin-2(1H)-on-3-carboxylic acid ethyl ester 
• 23612-57-9 (2-amino-3-pyridinyl)methanol 
• 7521-41-7 2-Aminonicotinaldehyde 

Relevant articles and documents

Method for preparing 2-amino-3-hydroxymethylpyridine

The invention discloses a method for preparing 2-amino-3-hydroxymethylpyridine, and belongs to the field of chemical synthesis. 2-aminopyridine and pivaloyl chloride are used as initial reactants to form intermediate product 2-pivalamidopyridine under the action of triethylamine, after hydrogen extraction by use of n-butyllithium, dimethylformamide is added for hydroformylation, and target product2-amino-3-hydroxymethylpyridine can be obtained by reduction with sodium borohydride. Raw materials used in the method are low in cost, and the method is simple in operation, short in synthesis process, mild in reaction conditions, high in yield, and suitable for large-scale industrial production.

HETEROCYCLIC CGRP RECEPTOR ANTAGONISTS

The present invention is directed to heterocyclic compounds which are antagonists of CGRP receptors and may be useful in the treatment or prevention of diseases in which CGRP is involved, such as migraine. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.

NOVEL ANTIMALARIA AGENT CONTAINING HETEROCYCLIC COMPOUND

Disclosed is an antimalarial agent containing a compound represented by the formula: [wherein A1 represents a 3-pyridyl group that may have a substituent, a 6-quinolyl group that may have a substituent, or the like; X1 represents a group represented by the formula -C(=O)-NH- or the like; E represents a furyl group, a thienyl group or a phenyl group; with the proviso that A1 may have one to three substituents, and E has one of two substituents] or a salt thereof or hydrates thereof.