2362-58-5

Basic information

• Product Name: 4-(4-METHYLPHENYL)-2-PHENYL-1,3-THIAZOLE
• Synonyms: 4-(4-METHYLPHENYL)-2-PHENYL-1,3-THIAZOLE
• CAS NO: 2362-58-5
• Molecular Formula: C₁₆H₁₃NS
• Molecular Weight: 251.35
• Mol File: 2362-58-5.mol
• Article Data: 15

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-(4-METHYLPHENYL)-2-PHENYL-1,3-THIAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(4-METHYLPHENYL)-2-PHENYL-1,3-THIAZOLE(2362-58-5)
• EPA Substance Registry System: 4-(4-METHYLPHENYL)-2-PHENYL-1,3-THIAZOLE(2362-58-5)

Safety Data

• Hazardous Substances Data: 2362-58-5(Hazardous Substances Data)

Upstream product

• 98475-04-8 1-(4-methylphenyl)-2-(p-tolylsulfonyloxy)ethanone 
• 2227-79-4 benzenecarbothioamide 
• 1826-11-5 2-phenylthiazole 
• 5720-05-8 4-methylphenylboronic acid 
• 122-00-9 para-methylacetophenone 
• 100-46-9 benzylamine 
• 766-97-2 4-n-methylphenylacetylene 
• 4209-24-9 p-methylphenacyl chloride 
• 2032-36-2 Thiobenzmorpholid 
• 619-41-0 4-(bromoacetyl)toluene 
• 622-97-9 1-ethenyl-4-methylbenzene 
• 591-50-4 iodobenzene 
• 98-88-4 benzoyl chloride 
• 66380-04-9 N-benzoyl-N-methyl-C-(4-methylphenyl)-glycine 

Downstream Products

• 951000-50-3 C₁₆H₁₂FNS 

Relevant articles and documents

Br?nsted acid-promoted thiazole synthesis under metal-free conditions using sulfur powder as the sulfur source

A Br?nsted acid-promoted sulfuration/annulation reaction for the one-pot synthesis of bis-substituted thiazoles from benzylamines, acetophenones, and sulfur powder has been developed. One C-N bond and multi C-S bonds were selectively formed in one pot. The choice of the Br?nsted acid was the key to the high efficiency of this transformation under metal-free conditions.

Visible Light-Induced Difunctionalization of Alkynes: The Synthesis of Thiazoles and 1,1-Dibromo-1-en-3-ynes

A visible light-induced cascade cyclization of thioamides with alkynes was developed to synthesize 1,3-thiozoles. The sulfur radical generated from thioamide via the single-electron transfer (SET) pathway was promoted by photocatalysis as a key intermediate in this reaction. When bromoalkynes were used as the substrate, the self-coupling products 1,1-dibromo-1-en-3-ynes were obtained in moderate yields, and an energy transfer pathway for this transformation promoted by visible-light photocatalysis was proposed.

One-Pot Preparation of Aromatic Amides, 4-Arylthiazoles, and 4-Arylimidazoles from Arenes

Simple treatment of arenes with α-bromoacetyl chloride and AlCl3, followed by the reaction with molecular iodine and aq. NH3, thioamides, or amidines gave the corresponding primary aromatic amides, 4-arylthiazoles, or 4-arylimidazoles in good yields, respectively. Aryl α-bromomethyl ketones are the key intermediates in those reactions. Primary aromatic amides were formed from arenes through the reaction of aryl α-bromomethyl ketones with molecular iodine and aq. NH3, and 4-arylthiazoles and 4-arylimidazoles were formed from arenes through the reactions of aryl α-bromomethyl ketones with thioamides and amidines, respectively, in one pot under transition-metal-free conditions.