23628-24-2Relevant articles and documents
Syntheses of Diverse Donor-Substituted Bisbenzofuro[2,3- b:3′,2′- e]pyridines (BBZFPys) via Pd Catalysis, and Their Photophysical Properties
Itai, Yuhei,Nishii, Yuji,Stachelek, Patrycja,Data, Przemyslaw,Takeda, Youhei,Minakata, Satoshi,Miura, Masahiro
, p. 10289 - 10302 (2018)
A series of bisbenzofuro[2,3-b:3′,2′-e]pyridines (BBZFPys) bearing a chlorine functionality have been efficiently synthesized through a Pd-catalyzed double oxidative intramolecular C-H/C-H coupling of monochlorinated 2,6-diaryloxypyridines. The subsequent
Substituent Effects of 2-Pyridones on Selective O-Arylation with Diaryliodonium Salts: Synthesis of 2-Aryloxypyridines under Transition-Metal-Free Conditions
Li, Xiao-Hua,Ye, Ai-Hui,Liang, Cui,Mo, Dong-Liang
, p. 1699 - 1710 (2018/02/06)
An efficient transition-metal-free strategy to synthesize 2-aryloxypyridine derivatives has been developed by a selective O-arylation of 2-pyridones with diaryliodonium salts. The reaction was compatible with a series of functional groups for 2-pyridones and diaryliodonium salts such as halides, nitro, cyano, and ester groups. The substituents at the C6-position of 2-pyridones favored O-arylation products because of steric hindrance. The reaction was easily performed on a gram-scale and 6-chloro-2-pyridone was a good precursor to access various unsubstituted 2-aryloxypyridines by dehalogenation. A P2Y 1 lead compound analogue could be prepared in good yield over two steps.
BIARYL DERIVATIVE AS GPR120 AGONIST
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Paragraph 0145, (2017/11/17)
The present invention relates to a biaryl derivative expressed by the chemical formula 1, a method for producing the biaryl derivative, a pharmaceutical composition comprising same, and use of same, the biaryl derivative expressed by the chemical formula 1, as a GPR120 agonist, promoting GLP-1 generation in the gastro-intestinal tract, reducing insulin resistance in the liver, muscles and the like from anti-inflammatory activity in the macrophage, pancreatic cells and the like, and allowing effective use in prevention or treatment of inflammation or metabolic diseases such as diabetes, complications from diabetes, obesity, non-alcoholic fatty liver disease, fatty liver disease, and osteoporosis.
Substituted piperazine derivatives, the preparation thereof and their use as medicaments
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, (2008/06/13)
The present invention relates to substituted piperazine derivatives of general formula wherein Ra, Rb, RcRf, Rgand m, n and X are defined as in claim 1, the isomers and salts thereof, particularly the
ON THE BIPYRIDYL FORMATION IN REACTIONS OF 2-CHLOROPYRIDINE DERIVATIVES WITH POTASSIUM AMIDE IN LIQUID AMMONIA
Streef, Johannis W.,Plas, Henk C. van der,Harkema, Sybolt
, p. 2313 - 2325 (2007/10/02)
In the reaction of 2,6-dichloropyridine and 2,6-dichloro-3-phenylpyridine with potassium amide in liquid ammonia at -70 deg C, formation of derivatives of 4,4'-bipyridyl and 3,4'-bipyridyl is observed.The 4,4' coupling products are far in excess to the 3,4' coupling products.When the reaction is carried out at -70 deg C in the presence of potassium permanganate, the corresponding 4-aminopyridines are the main products. 2-Chloro-6-phenoxypyridine is very unreactive with this aminating reagent at -70 deg C as well as -33 deg C, but in the presence of potassium permanganate at -33 deg C 4-amino-2-chloro-6-phenoxypyridine is formed in fair yield.The mechanisms of the formation of the bipyridyls and 4-aminopyridines are presented.
