2367-75-1

Upstream product

• 446-35-5 2,4-Difluoronitrobenzene 
• 70-34-8 2,4-Dinitrofluorobenzene 
• 51796-81-7 1-bromo-2-chloro-3,5-dinitrobenzene 

Downstream Products

• 1356493-58-7 3-cyclopropyl-4-fluoro-5-(1H-tetrazol-1-yl)benzenamine 
• 1356493-57-6 1-(3-cyclopropyl-2-fluoro-5-nitrophenyl)-1H-tetrazole 
• 1356493-56-5 3-cyclopropyl-2-fluoro-5-nitroaniline 
• 1356493-35-0 N₂-(3-cyclopropyl-4-fluoro-5-(1H-tetrazol-1-yl)phenyl)-5-fluoro-N₄-(2,2,6,6-tetramethylpiperidin-4-yl)pyrimidine-2,4-diamine 
• 1356493-34-9 2-(3-cyclopropyl-4-fluoro-5-(1H-tetrazol-1-yl)phenylamino)-4-(2,2,6,6-tetramethylpiperidin-4-ylamino)pyrimidine-5-carbonitrile 
• 1309833-32-6 3-bromo-2-fluoro-5-nitrobenzenamine 
• 1356493-55-4 5-bromo-4-fluorobenzene-1,3-diamine 
• 1356493-54-3 3-bromo-4-fluoro-5-nitrobenzenamine 

Relevant academic research and scientific papers

Elemental Fluorine as an 'Enabler' for Generation of Powerful Electrophiles from Other Halogens

A new direct iodination procedure for aromatic systems involves iodine, substrate, sulfuric acid, and elemental fluorine at room temperature.

PROTEIN KINASE C INHIBITORS AND USES THEREOF

This disclosure concerns compounds which are useful as inhibitors of protein kinase C (PKC) and are thus useful for treating a variety of diseases and disorders that are mediated or sustained through the activity of PKC. This disclosure also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.

Halogenation reactions

A method of halogenating an aromatic compound which comprises the steps of reacting an halogenating agent with the aromatic compound in the presence of fluorine and an acid, wherein the halogenating agent is at least one of an iodinating agent, a brominating agent and an chlorinating agent.

Elemental fluorine. Part 4. Use of elemental fluorine for the halogenation of aromatics

New methodolgy for direct iodination of benzenoid compounds has been developed; the aromatic substrate is simply mixed with iodine and sulfuric acid, suspended in an inert medium, such as 1,1,2-trichlorotrifluoroethane (CF2ClCFCl2) or perfluorocarbon, and elemental fluorine is passed through the system at room temperature. High conversions to iodoaromatic products occur, even with some deactivated systems, e.g. nitrobenzene. A very powerful brominating system is produced using the analagous methodology.

BROMINATION OF DEACTIVATED AROMATIC COMPOUNDS

Unreactive aromatic compounds can be brominated with high yields by the action of bromine and nitric acid or another oxidizing agent (iodic acid, hydrogen peroxide, etc.) in concentrated sulfuric acid or oleum.Bromination in the presence of nitric acid has lower substrate selectivity than the concurrent nitration.Moderately deactivated aromatic substrates are nitrated initially, whereas inactive substrates are brominated.It is suggested that the electrophilic brominating agent is sulfohypobromite in the form of a complex with sulfuric acid.