51796-81-7

Upstream product

• 2316-50-9 2-bromo-4,6-dinitrophenol 
• 98-59-9 p-toluenesulfonyl chloride 
• 91-66-7 N,N-diethylaniline 
• 100-00-5 4-chlorobenzonitrile 
• 97-00-7 1-chloro-2,4-dinitro-benzene 

Downstream Products

• 91330-95-9 (2-bromo-4,6-dinitro-phenyl)-phenyl-amine 
• 26103-32-2 1,3-Dinitro-phenoxazin 
• 109019-06-9 N-(2-bromo-4,6-dinitro-phenyl)-N'-phenyl-hydrazine 
• 56205-34-6 3-(2-bromo-4,6-dinitro-phenyl)-2-thioxo-thiazolidin-4-one 
• 68142-45-0 5-benzylidene-3-(2-bromo-4,6-dinitro-phenyl)-2-thioxo-thiazolidin-4-one 
• 68142-29-0 3-(2-bromo-4,6-dinitro-phenyl)-5-(4-methoxy-benzylidene)-2-thioxo-thiazolidin-4-one 
• 3396-34-7 morpholine-4-carbodithioic acid 2-bromo-4,6-dinitro-phenyl ester 
• 93308-01-1 2-Brom-4,6-dinitro-2'-amino-4'-methyl-diphenylamin 
• 57221-26-8 p-Chlorophenyl-2-bromo-4,6-dinitrophenyl-sulfid 
• 1817-73-8 2-bromo-4,6-dinitroaniline 
• 2576-21-8 (2-bromo-4,6-dinitro-phenyl)-acetone 
• 101495-42-5 (2-bromo-4,6-dinitro-phenyl)-acetic acid 
• 57221-37-1 p-Chlorophenyl-2-bromo-4,6-dinitrophenyl-sulfon 
• 475095-97-7 methyl (2-bromo-4,6-dinitrophenylsulphanyl)ethanoate 

Relevant academic research and scientific papers

CYCLIC COMPOUNDS AND USES THEREOF

The invention generally relates to substituted benzothiophenyl, substituted benzothiazolyl, substituted indolyl and substituted benzoimidazolyl compounds and, more particularly, to a compound represented by Structural Formula I: or a pharmaceutically acceptable salt thereof, wherein the variables are as defined and described herein. The invention also includes the synthesis and use of a compound of Structural Formula I, or a pharmaceutically acceptable salt or composition thereof, e.g., in the treatment of a disease or disorder selected from cancer (e.g., lymphoma, such as mantle cell lymphoma), a neurodegenerative disease, inflammatory diseases or an autoimmune system disease (e.g., a T-Cell mediated autoimmune disesase).

Bromination of deactivated aromatics: A simple and efficient method

(Chemical Equation Presented) Highly deactivated aromatic compounds were smoothly monobrominated by treatment with N-bromosuccinimide (NBS) in concentrated H2SO4 medium affording the corresponding bromo derivatives in good yields. Mild reaction conditions and simple workup provides a practical and commercially viable route for the synthesis of bromo compounds of deactivated aromatics.

Preparation of substituted methyl o-nitrophenyl sulfides

The nucleophilic substitution of substituted o-nitrochlorobenzenes with substituted methanethiolates, catalysed with triethylamine or pyridine, has been used to prepare a series of appropriately substituted methyl-o- nitrophenylsulfides. The prepared compounds were identified by their 1H- and 13C-NMR spectra. The base catalysed ring closure of methyl 2-(methoxycarbonylmethylsulfanyl)-3,5-dinitrobenzenecarboxylate only results in an attack of carbanion on the ester group, not on a nitro group as with the other compounds prepared. The cyclisation product is methyl 3-hydroxy-5,7-dinitro-benzo[b]thiophene-2-carboxylate (11).

BROMINATION OF DEACTIVATED AROMATIC COMPOUNDS

Unreactive aromatic compounds can be brominated with high yields by the action of bromine and nitric acid or another oxidizing agent (iodic acid, hydrogen peroxide, etc.) in concentrated sulfuric acid or oleum.Bromination in the presence of nitric acid has lower substrate selectivity than the concurrent nitration.Moderately deactivated aromatic substrates are nitrated initially, whereas inactive substrates are brominated.It is suggested that the electrophilic brominating agent is sulfohypobromite in the form of a complex with sulfuric acid.