236749-60-3Relevant academic research and scientific papers
Synthesis of a reaction intermediate analogue of biotin-dependent carboxylases via a selective derivatization of biotin
Amspacher, David R.,Blanchard, Carol Z.,Fronczek, Frank R.,Saraiva, Marcelo C.,Waldrop, Grover L.,Strongin, Robert M.
, p. 99 - 102 (2008/02/11)
An efficient and practical synthesis of 1, a unique reaction intermediate analogue of biotin-dependent carboxylases, is described. The synthesis features a selective acylation of the 1′-N of biotin. Target 1 inhibits the activity of the biotin carboxylase
