236754-84-0

Upstream product

• 868-85-9 Dimethyl phosphite 
• 181999-83-7 1-(2,5,6-trideoxy-6,6-dibromo-3-O-(tert-butyldiphenylsilyl)-β-D-erythro-hex-5-enofuranosyl)-5-methyluracil 
• 58479-61-1 tert-butylchlorodiphenylsilane 
• 83467-48-5 1-[(2R,4S,5R)-4-(tert-butyldiphenylsilanyloxy)-5-hydroxymethyltetrahydrofuran-2-yl]-5-methyl-1H-pyrimidine-2,4-dione 
• 50-89-5 thymidine 
• 40733-28-6 5'-tert-butyldimethylsilyloxy-2'-deoxythymidine 
• 146604-43-5 1-(2-deoxy-3-O-tert-butyldiphenylsilyl-β-D-erythro-pentadialdo-1,4-furanosyl)-5-methyluracil 

Downstream Products

• 40733-28-6 5'-tert-butyldimethylsilyloxy-2'-deoxythymidine 
• 289711-56-4 C₁₀H₁₄N₂O₄CSiC₁₆H₁₆C₁₀H₁₄N₂O₅PO₂CH₃SiC₆H₁₄ 

Relevant academic research and scientific papers

Commercially available 5'-DMT phosphoramidites as reagents for the synthesis of vinylphosphonate-linked oligonucleic acids.

[reaction: see text]. Commercially available cyanoethyl phosphoramidites derived from T, d(C), d(A), and d(G) were hydrolyzed (1H-tetrazole, MeCN/H2O) to give the corresponding H-phosphonates in excellent yields. Palladium(0)-catalyzed cross-coupling of e

The 'Hirao reduction' revisited: A procedure for the synthesis of terminal vinyl bromides by the reduction of 1,1-dibromoalkenes

A convenient procedure for the synthesis of vinyl bromides is described, which involves the selective reduction of the corresponding 1,1- dibromoalkenes with dimethylphosphite and triethylamine. The 1,1- dibromoalkenes are obtained in excellent yields fro

A novel palladium-catalysed coupling strategy for the rapid synthesis of nucleic acid analogues bearing modified backbones

The synthesis of a 5'-deoxy-5'-methylidene phosphonate-containing thymidine dimer 14 has been achieved using a palladium-catalysed cross coupling reaction as a key step. The E-vinyl bromide 9 was synthesised from the corresponding 1,1-dibro-moolefin 7 via