289711-56-4

Upstream product

• 236754-86-2 C₁₀H₁₄N₂O₅SiC₆H₁₄PO₂CH₃ 
• 236754-84-0 (E)-6'-bromo-(5'-deoxy-5'-methylidene)-3'-O-(tert-bytuldiphenylsilyl)thymidine 
• 146604-43-5 1-(2-deoxy-3-O-tert-butyldiphenylsilyl-β-D-erythro-pentadialdo-1,4-furanosyl)-5-methyluracil 
• 40733-28-6 5'-tert-butyldimethylsilyloxy-2'-deoxythymidine 
• 166758-13-0 5'-O-(tert-butyldimethylsilyl)-3'-O-(tert-butyldiphenylsilyl)thymidine 
• 181999-83-7 1-(2,5,6-trideoxy-6,6-dibromo-3-O-(tert-butyldiphenylsilyl)-β-D-erythro-hex-5-enofuranosyl)-5-methyluracil 
• 50-89-5 thymidine 
• 58479-61-1 tert-butylchlorodiphenylsilane 
• 236754-85-1 diisopropyl-phosphoramidous acid 2-(tert-butyl-dimethyl-silanyloxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester methyl ester 
• 83467-48-5 1-[(2R,4S,5R)-4-(tert-butyldiphenylsilanyloxy)-5-hydroxymethyltetrahydrofuran-2-yl]-5-methyl-1H-pyrimidine-2,4-dione 
• 364063-63-8 vinyl-phosphonic acid 2-(tert-butyl-dimethyl-silanyloxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester methyl ester 

Relevant academic research and scientific papers

Commercially available 5'-DMT phosphoramidites as reagents for the synthesis of vinylphosphonate-linked oligonucleic acids.

[reaction: see text]. Commercially available cyanoethyl phosphoramidites derived from T, d(C), d(A), and d(G) were hydrolyzed (1H-tetrazole, MeCN/H2O) to give the corresponding H-phosphonates in excellent yields. Palladium(0)-catalyzed cross-coupling of e

An Olefin cross-metathesis approach to vinylphosphonate-linked nucleic acids

(Equation presented) The synthesis of vinylphosphonate-linked nucleotide dimers has been achieved using an olefin cross-metathesis (CM) reaction as a key step. The 1,3-dimesityl-4,5-dihydroimidazol-2-ylidine-containing catalyst 5 (Grubbs' second-generatio

An improved procedure for the synthesis of vinylphosphonate-linked nucleic acids

The synthesis of a range of 5'-deoxy-5'-methylidene phosphonate- containing thymidine dimers has been achieved using a palladium-catalysed cross coupling reaction as a key step. The optimised reaction conditions comprising of palladium acetate, 1,1'-bis(diphenylphosphino)ferrocene and propylene oxide in THF were found to couple a range of H-phosphonates and vinyl bromide 3 in fair to excellent yield. (C) 2000 Elsevier Science Ltd.

A novel palladium-catalysed coupling strategy for the rapid synthesis of nucleic acid analogues bearing modified backbones

The synthesis of a 5'-deoxy-5'-methylidene phosphonate-containing thymidine dimer 14 has been achieved using a palladium-catalysed cross coupling reaction as a key step. The E-vinyl bromide 9 was synthesised from the corresponding 1,1-dibro-moolefin 7 via