23694-02-2

Usage

Uses

Used in Pharmaceutical Industry:
Ethanone, 2-chloro-1-(1-methyl-1H-pyrrol-2-yl)(9CI) is used as an intermediate in the synthesis of pharmaceuticals for its ability to contribute to the formation of complex organic molecules that can exhibit therapeutic properties.
Used in Organic Synthesis:
In the field of organic synthesis, Ethanone, 2-chloro-1-(1-methyl-1H-pyrrol-2-yl)(9CI) is utilized as a building block for the creation of various chemical compounds, enabling the development of new materials and substances with potential applications in different industries.
Used in Research and Development:
Ethanone, 2-chloro-1-(1-methyl-1H-pyrrol-2-yl)(9CI) is employed in research and development as a component in the synthesis of novel chemical compounds, aiding scientists in exploring new avenues for chemical innovation and discovery.
Safety Precautions:
Due to its toxic and hazardous properties, Ethanone, 2-chloro-1-(1-methyl-1H-pyrrol-2-yl)(9CI) should be handled and used with caution in appropriate laboratory settings to ensure the safety of personnel and the environment.

InChI:InChI=1/C7H8ClNO/c1-9-4-2-3-6(9)7(10)5-8/h2-4H,5H2,1H3

Upstream product

• 96-54-8 N-Methylpyrrole 
• 2620-05-5 N-methyl-2-chloroacetanilide 
• 2675-89-0 2-chloro-N,N-dimethylacetamide 
• 932-16-1 N-methyl-2-acetylpyrrole 
• 31785-72-5 1-methyl-2-pyrrolyllithium 
• 619-33-0 dichloroacetaldehyde diethyl acetal 
• 79-04-9 chloroacetyl chloride 

Downstream Products

• 76007-21-1 1-methyl-2-N-methylanilinoacetylpyrrole 
• 157847-53-5 2-chloro-1-[4-(4-chlorobenzoyl)-1-methyl-1H-pyrrol-2-yl]-ethanone 
• 76007-27-7 3-(1-methylpyrrol-2-yl)-1-phenylazetidin-3-ol 
• 21391-29-7 1-(α-N-Methyl-pyrryl)-2-piperidino-ethanol 

Relevant academic research and scientific papers

The α-chlorination of aryl methyl ketones under aerobic oxidative conditions

The novel reaction system air/ammonium nitrate/iodine/hydrochloric acid [air/NH4NO3(cat.)/I2(cat.)/HCl] is introduced as a simple, safe, cheap, efficient and regioselective mediator for the α-chlorination of aryl, heteroaryl and alkyl methyl ketones under aerobic oxidative conditions. The inventive use of a catalytic amount of iodine enabled the moderate to quantitative, regioselective chlorination of a comprehensive scope of different methyl ketone derivatives including those bearing oxidizable heteroatom (S, N) substituents, some of which possess declared potential biological and pharmaceutical activity. Air oxygen under a slight overpressure plays the role of the terminal oxidant catalytically activated by redox cycles of nitrogen oxides released from the catalytic amount of ammonium nitrate (NH4NO3) under acidic conditions of hydrochloric acid (HCl) and co-catalyzed by elemental iodine (I2), which was found to be essential for the high efficiency of the reaction system.

Solvent free synthesis of 2-acylpyrroles and its derivatives catalysed by reuseable zinc oxide

A highly efficient procedure for preparing 2-acylpyrroles and its derivatives is described. The products were obtained through regioselective Friedel-Crafts reactions of pyrroles and its derivatives with alkyl or aryl acid chlorides catalysed by zinc oxide under solvent-free conditions. This method has the advantages of green chemistry, operational simplicity, solvent-free conditions, and recoverable catalyst.

Enantioselective synthesis of heteroaromatic epoxyketones under phase-transfer catalysis using D-glucose- and D-mannose-based crown ethers

Heteroaromatic epoxyketones have been synthesized in an asymmetric Darzens condensation of 2-chloroacetylfuran or 2- and 3-chloroacetylthiophene with aromatic aldehydes and in the enantioselective epoxidation of α,β-enones with an N-methylpyrrole unit, in

Spectroscopic and theoretical studies on some new pyrrol-2-yl-chloromethyl ketones

A novel series of pyrrole-2-yl chloromethyl ketones were synthesized and studied by FT-IR, 1H, 13C NMR spectroscopy and DFT calculations at the B3LYP/6-311++G(d,p) level of approximation. Two stable conformations were detected in solution: s-cis and s-trans forms where the C=O group is located on the same side or the opposite side of N-H group, respectively. The conformational stability of these molecules is governed mainly by intermolecular hydrogen bonding interactions. The strength of hydrogen bonds was evaluated on the basis of 1H chemical shift and infrared red shift ΔνN-H of the stretching vibration of N-H proton donating bonds. The quantum theory of 'atoms in molecules' as well as the natural bond orbital method were applied to characterize hydrogen bonding interactions. The Royal Society of Chemistry and the Centre National de la Recherche Scientifique 2010.

Novel building blocks: 1-Aryl-2-chloro-1-ethoxyethenes - Preparations and transformations

We described here a simple method for the preparation of 1-aryl-2-chloro-1-ethoxyethenes 2a-u, which are prodrugs for Alzheimer's disease, by the reaction of dichloroacetaldehyde diethyl acetal with various aryl and alkenyllithium compounds in high yields. Wiley-VCH Verlag GmbH & Co. KGaA, 2007.

Ytterbium (III) trifluoromethanesulfonate catalysed Friedel-Crafts acylation of 1-methylpyrrole in ionic liquid

In the presence of a catalytic amount of ytterbium (III) trifluoromethanesulfonate [Yb(OTf)3], 1-methylpyrrole can easily react with acyl chlorides in an ionic liquid [bpy][BF4](bpy=1- butylpyridine) to form corresponding ketones in satisfactory yield. The recyclability of the ionic liquid/catalyst system is demonstrated.

Design, synthesis, and biological activities of pyrrolylethanoneamine derivatives, a novel class of monoamine oxidases inhibitors

Pyrrolylethanoneamines 1-12, 18-23 and related amino alcohols 13-15, 24-27 were synthesized and tested against monoamine oxidases A and B (MAO-A and MAO-B) enzymes. In general, aminoketones 1-12, 18-23 were found to be potent and selective MAO-A inhibitor

Aroyl aminoacyl pyrroles for use in the treatment of neuropathic pain

Aroyl aminoacyl pyrroles are pharmaceutically useful in treating neuropathic pain, which includes utility for the treatment of neuropathic pain.

Aroyl aminoacyl pyrroles for use in the treatment of neuropathic pain

Aroyl aminoacyl pyrroles are pharmaceutically useful in treating neuropathic pain, which includes utility for the treatment of neuropathic pain.

Anti-convulsant aroyl aminoacylpyrroles

Aroyl aminoacyl pyrroles are pharmaceutically useful as anti-convulsants, which includes utility for the treatment of epilepsy.