23702-98-9

Basic information

• Product Name: PHENYL-PIPERIDIN-2-YL-METHANOL
• Synonyms: PHENYL-PIPERIDIN-2-YL-METHANOL
• CAS NO: 23702-98-9
• Molecular Formula: C₁₂H₁₇NO
• Molecular Weight: 191.27
• Mol File: 23702-98-9.mol
• Article Data: 11

Chemical Properties

• Melting Point: 134-136°C
• Boiling Point: 311.3°Cat760mmHg
• Flash Point: 113.2°C
• Appearance: /
• Density: 1.068g/cm³
• Vapor Pressure: 0.000244mmHg at 25°C
• Refractive Index: 1.55
• PKA: 14.27±0.20(Predicted)
• CAS DataBase Reference: PHENYL-PIPERIDIN-2-YL-METHANOL(CAS DataBase Reference)
• NIST Chemistry Reference: PHENYL-PIPERIDIN-2-YL-METHANOL(23702-98-9)
• EPA Substance Registry System: PHENYL-PIPERIDIN-2-YL-METHANOL(23702-98-9)

Safety Data

• Hazardous Substances Data: 23702-98-9(Hazardous Substances Data)

Usage

General Description

PHENYL-PIPERIDIN-2-YL-METHANOL is a chemical compound with a molecular formula of C13H19NO. It is a white solid with a molecular weight of 205.3 g/mol and is commonly used as a pharmaceutical intermediate in the synthesis of various drugs. PHENYL-PIPERIDIN-2-YL-METHANOL has been studied for its potential use as a psychoactive substance, and it is a member of the piperidine class of compounds, which are known for their diverse pharmacological properties. Additionally, PHENYL-PIPERIDIN-2-YL-METHANOL has been investigated for its potential as a building block in the synthesis of compounds with analgesic and antitussive properties. Overall, this compound has shown promise for various pharmaceutical applications and continues to be the focus of research for its potential therapeutic uses.

InChI:InChI=1/C12H17NO/c14-12(10-6-2-1-3-7-10)11-8-4-5-9-13-11/h1-3,6-7,11-14H,4-5,8-9H2

Upstream product

• 95018-47-6 {1-[(E)-tert-Butylimino-methyl]-1,4,5,6-tetrahydro-pyridin-2-yl}-phenyl-methanol 
• 91-02-1 phenyl(pyridin-2-yl)methanone 
• 85152-52-9 N-(N'-tert-butylformimidoyl)piperidine 
• 123387-56-4 erythro-N-(tert-butoxycarbonyl)-α-phenyl-2-piperidinemethanol 
• 7647-01-0 hydrogenchloride 
• 7732-18-5 water 
• 5583-31-3 erythro-α-phenyl-2-piperidinemethanol 
• 42510-59-8 threo-8-oxa-7-phenyl-1-azabicyclo<4.3.0>nonan-9-one 
• 120153-69-7 2-Benzoyl-piperidine-1-carboxylic acid phenyl ester 
• 120153-68-6 N-benzylpiperidine-2-carbonitrile 
• 75844-69-8 t-butyl piperidinecarboxylate 
• 101-82-6 2-Benzylpyridine 
• 729553-31-5 (1-Benzyl-piperidin-2-yl)-phenyl-methanone 

Downstream Products

• 5583-31-3 threo-α-phenyl-2-piperidinemethanol 
• 32838-55-4 2-benzylpiperidine 
• 23702-99-0 rac-piperidin-2-yl-phenylmethanone 
• 203056-28-4 (S)-N-(tert-butyloxycarbonyl)piperidin-2-yl-phenylmethanone 
• 203056-16-0 (R)-N-(tert-butyloxycarbonyl)piperidin-2-yl-phenylmethanone 
• 5583-31-3 (αR,2S)-phenyl 2-piperidyl methanol 
• 870842-48-1 (E)-1-[2-(hydroxyphenylmethyl)piperidin-1-yl]-3-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]propenone 
• 78383-56-9 hexahydro-1'-benzyl-1-phenylspiro[3H-oxazolo[3,4-a]-pyridine-3,4'-piperidine] 
• 615571-37-4 threo-(1-ethylpiperidin-2-yl)phenylmethanol 
• 102960-86-1 1,3-diphenyl-octahydro-pyrido[2,1-c][1,4]oxazine 
• 95372-85-3 1-phenyl-octahydro-pyrido[2,1-c][1,4]oxazine 
• 203309-44-8 1-(2-Hydroxy-ethyl)-2-(α-hydroxy-benzyl)-piperidin 
• 5583-07-3 (8aR or 8aS)-1t-phenyl-(8ar)-hexahydro-oxazolo[3,4-a]pyridin-3-ylideneamine 
• 5583-07-3 (8aR or 8aS)-1c-phenyl-(8ar)-hexahydro-oxazolo[3,4-a]pyridin-3-ylideneamine 

Relevant articles and documents

Synthetic Cathinone Analogues Structurally Related to the Central Stimulant Methylphenidate as Dopamine Reuptake Inhibitors

Synthetic cathinones are, primarily, stimulant drugs of abuse that act at monoamine transporters (e.g., the dopamine transporter or DAT) as releasing agents or as reuptake inhibitors. In the past few years, the emergence of >150 new synthetic cathinones has attracted considerable attention from medical and law enforcement communities. threo-Methylphenidate (tMP), used clinically for the treatment of ADHD and narcolepsy, is also a DAT reuptake inhibitor. tMP is somewhat structurally similar to abused cathinone stimulants, and the structure-activity relationships (SAR) of tMP have been well-defined. Hence, available tMP literature might assist in understanding the SAR of synthetic cathinones, about which less is known. In the present study, we synthesized and examined eight 2-benzoylpiperidine analogues (4, 6-12) to determine if tMP SAR might be applicable to cathinone SAR. The benzoylpiperidine analogues were evaluated in a competition assay using live-cell imaging against APP+ in HEK293 cells stably expressing hDAT and in cells coexpressing DAT and voltage-gated Ca2+ channels. All compounds were found to be DAT reuptake inhibitors, and a significant correlation was obtained between the potency of the benzoylpiperidines and tMP binding data (r = 0.91), suggesting that the SAR of tMP analogues might be directly applicable to certain synthetic cathinones as DAT reuptake inhibitors.

Concise preparation of a stable cyclic sulfamidate intermediate in the synthesis of a enantiopure chiral active diamine derivative

A classical resolution was studied and developed from 2-benzoyl-pyridine in order to prepare SSR504734, a novel antipsychotic derivative. The key step of this route is the substitution of a sulfamidate derivative by a benzamide anion with complete inversi

Partial hydrogenation of substituted pyridines and quinolines: A crucial role of the reaction conditions

Hydrogenation of pyridyl and quinolyl compounds 2-substituted with a carbonyl group (1a-c and 2b,c) using PtO2 and 1 equiv. of HCl (conditions A) provides clean and total formation of the desired amino alcohol (hydrogenation of the heterocyclic ring and of the carbonyl) while under conditions B1 and/or B2 (concentrated HCl or pure CF 3CO2H) the heterocyclic ring remains untouched and other aromatic parts are hydrogenated providing complex mixtures. When the heterocyclic ring is substituted by an alkyl group (quinaldine 3) conditions A provide mixtures while under conditions B2 (pure CF 3CO2H) the benzene ring is cleanly hydrogenated leading to a pure product.