2371-26-8

Basic information

• Product Name: ethyl N-(3,4-dimethylphenyl)glycinate
• Synonyms: glycine, N-(3,4-dimethylphenyl)-, ethyl ester
• CAS NO: 2371-26-8
• Molecular Formula: C₁₂H₁₇NO₂
• Molecular Weight: 207.2689
• Mol File: 2371-26-8.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 309.6°C at 760 mmHg
• Flash Point: 141.1°C
• Density: 1.065g/cm³
• Vapor Pressure: 0.000632mmHg at 25°C
• Refractive Index: 1.541
• CAS DataBase Reference: ethyl N-(3,4-dimethylphenyl)glycinate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl N-(3,4-dimethylphenyl)glycinate(2371-26-8)
• EPA Substance Registry System: ethyl N-(3,4-dimethylphenyl)glycinate(2371-26-8)

Safety Data

• Hazardous Substances Data: 2371-26-8(Hazardous Substances Data)

Usage

General Description

Ethyl N-(3,4-dimethylphenyl)glycinate is a chemical compound that belongs to the class of glycine derivatives. It is a white to light yellow solid substance that is used in the manufacturing of pharmaceuticals, agrochemicals, and other organic compounds. ethyl N-(3,4-dimethylphenyl)glycinate is primarily used as an intermediate in the synthesis of various drugs and pesticides. Its chemical structure contains an ethyl group, a glycine derivative, and a 3,4-dimethylphenyl group, giving it versatile chemical properties and applications. Ethyl N-(3,4-dimethylphenyl)glycinate is commonly found in research laboratories and industrial settings where organic synthesis and chemical manufacturing are performed.

Upstream product

• 105-39-5 chloroacetic acid ethyl ester 
• 95-64-7 4-amino-o-xylene 
• 924-44-7 glyoxylic acid ethyl ester 
• 105-36-2 ethyl bromoacetate 

Downstream Products

• 669695-84-5 1-(3,4-dimethyl-phenyl)-imidazolidine-2,4-dione 
• 86323-99-1 [(3,4-Dimethyl-phenyl)-(3-mercapto-2-methyl-propionyl)-amino]-acetic acid 

Relevant articles and documents

4-Pyridone-3-carboxylic acid as a benzoic acid bioisostere: Design, synthesis, and evaluation of EP300/CBP histone acetyltransferase inhibitors

Histone acetyltransferases (HATs) play a crucial role in post-translational modification. Among them, overexpression, mutation, or hyperfunction of EP300/CBP has been associated with various cancers. In this study, we identified the novel compound 2-chloro-5-[5-[(E)-[1-(3-chlorophenyl)-3-methyl-5-oxo-pyrazol-4-ylidene]methyl]-2-furyl]benzoic acid (1) as an EP300 HAT inhibitor via virtual screening. Further research has been focused on the design, synthesis, and in vitro biological evaluation of virtual hit derivatives. The studies revealed that 4-pyridone-3-carboxylic acid derivatives exhibited bioisosterism of benzoic acid. Replacement proved effective, providing compounds with similar EP300 HAT-inhibitory activity and improved cell growth-inhibitory activity compared to the benzoic acid analogs. Through these studies, we identified a potent and selective EP300/CBP HAT inhibitor.

Enantioselective synthesis of arylglycine derivatives by direct C-H oxidative cross-coupling

A new method for the synthesis of chiral α-amino acid derivatives by enantioselective C-H arylation of N-aryl glycine esters with aryl boric acids in the presence of a chiral Pd(ii)-catalyst has been developed. This work successfully integrates the direct C-H oxidation with asymmetric arylation and exhibits excellent enantioselectivity. This journal is