23730-18-9

Upstream product

• 68899-97-8 N-((tert-butylimino)methylene)-4-methylbenzenesulfonamide 
• 19411-70-2 N-tert-butyl-N'-methylcarbodiimide 
• 4104-47-6 N-sulfinyl-p-toluenesulfonamide 
• 70-55-3 toluene-4-sulfonamide 
• 1609-86-5 Tert-butyl isocyanate 
• 98-59-9 p-toluenesulfonyl chloride 
• 941-55-9 4-toluenesulfonyl azide 
• 201230-82-2 carbon monoxide 
• 75-64-9 tert-butylamine 
• 4083-64-1 Tosyl isocyanate 
• 1424-52-8 p-tolylsulfonyl isothiocyanate 
• 25347-94-8 N-tert-Butyl-N'-methylharnstoff 
• 105143-05-3 N-tert-butyl-N'-(toluene-4-sulfonyl)-thiourea 

Relevant academic research and scientific papers

Synthesis method of tertiary butyl isocyanate

The invention relates to a synthesis method of tertiary butyl isocyanate. The method comprises the following steps of mixing an inert solvent and para toluene sulfonamide, introducing phosgene at 100DEG C to 120 DEG C, feeding an inert gas for driving gas after reaction, and thus obtaining a first reaction solution; at 0 DEG C to 20 DEG C, dropwise adding tert-butylamine into the first reaction solution, heating and refluxing for 4h or more, and thus obtaining a second reaction solution; separating and purifying the second reaction solution to obtain tertiary butyl isocyanate. According to the synthesis method of tertiary butyl isocyanate, the stability and the yield of the process can be improved, and the purity of the obtained tertiary butyl isocyanate product is higher.

A sulfonyl urea, sulfonamide ethyl ester preparation method of compound (by machine translation)

The description relates to a compound of formula (I) compound of the preparation method, wherein formula (II) with a compound represented by formula (III) as shown in the catalysis of palladium catalyst, under a carbon monoxide atmosphere, reacts in a solvent to obtain the compound. The invention related to the method of the reaction do not require strict-free conditions, does not need a high pressure carbon monoxide atmosphere, convenient and simple to operate, to a functional group and has very high power density and universality, the catalyst consumption is very small, the cost of reaction is very low, and can be widely used for preparing sulfonyl urea compound. R1 - SO2 - NH - CO - X (R3 )n - R2 (I) R1 - SO2 - R4 (II) HX (R3 )n - R2 (III) wherein X is O or N; n is 0 or 1; when X is when O, n=0; when X is when N, n=1; R1 Selected from aryl, heteroaryl, alkyl, alkenyl or alkynyl; R2 Selected from aryl, heteroaryl, alkyl, alkenyl or alkynyl; R3 Is selected from H, R2 , Or R3 And R2 A ring of connection; R4 For N3 Or a halogen atom; when R4 For nails halogen original, system also comprises a sodium azide. (by machine translation)

Product-Derived Bimetallic Palladium Complex Catalyzes Direct Carbonylation of Sulfonylazides

A novel product-derived bimetallic palladium complex catalyzes a sulfonylazide-transfer reaction with the σ-donor/π-acceptor ligand CO, and is advantageous given its broad substrate scope, high efficiency, and mild reaction conditions (atmospheric pressure of CO at room temperature). This methodology provides a new approach to sulfonylureas, which are present in both pharmaceuticals and agrochemicals. The synthesis of Glibenclamide on a gram scale further revealed the practical utility of this procedure. Mechanistically, the generation of a bridged bimetallic palladium species derived from the product sulfonylurea is disclosed as the crucial step for this catalytic cycle.

An improved method for the synthesis of sulfonylureas

Treatment of isocyanates with sulfonamides in dimethylformamide in the presence of copper(I) chloride affords sulfonylureas in high yields under mild conditions.