23731-50-2

Upstream product

• 2024-83-1 veratronitrile 
• 100-59-4 phenylmagnesium chloride 
• 98-88-4 benzoyl chloride 
• 4038-14-6 3,4-dimethoxybenzophenone 
• 108716-28-5 (3,4-dimethoxyphenyl)(phenyl)methanone oxime 

Downstream Products

• 23731-48-8 1-<3,4-Dimethoxy-phenyl>-1-phenyl-dimethylamin 
• 1496524-36-7 isopropyl((2S)-1-(((3,4-dimethoxylphenyl)(phenyl)methyl)amino)-3-methyl-1-oxobutan-2-yl)carbamate 

Relevant academic research and scientific papers

A su ammonia amide carbamate derivative and application thereof

The invention belongs to the field of plant bactericide, and relates to a threonyl amine carbamate derivative shown as the general formula (I) and salt capable of being accepted pharmaceutically. Substituent groups R1, R2 and R3 have the definitions given by a specification. The invention further relates to a preparation method of the compound of the general formula (I), a midbody specially developed for preparing the threonyl amine carbamate derivative and an application of the threonyl amine carbamate derivative in plant disease prevention and control. The formula is shown in the specification.

Design, synthesis, and fungicidal activity of novel carboxylic acid amides represented by N-benzhydryl valinamode carbamates

Carboxylic acid amide (CAA) fungicides are an important class of agricultural fungicide with oomycete activity and low toxicity toward mammalian cells. To find CAA analogues with high activity against resistant pathogens, a series of substituted N-benzhydryl valinamide carbamate derivatives were designed and synthesized by introducing substituted aromatic rings into valinamide carbamate leads. Bioassays showed that some title compounds exhibited very good in vitro fungicidal activity against Phytophthora capsici and in vivo fungicidal activities against Pseudoperonospora cubensis. Topomer CoMFA was performed to explore the structure-activity relationship on the basis of the in vitro data. The dimethoxy substituted aromatic analogue 9e was found to display higher in vitro fungicidal activity against Phytophthora capsici than iprovalicarb but lower activity than mandipropamid, and higher in vivo fungicidal activity against Pseudoperonospora cubensis than dimethomorph at a dosage of 6.25 μg mL-1. This journal is the Partner Organisations 2014.

Rapid, one-pot synthesis of α,α-disubstituted primary amines by the addition of Grignard reagents to nitriles under microwave heating conditions

A series of α,α-disubstituted amines have been prepared in a simple and efficient one-pot procedure by the addition of Grignard reagents to a series of aliphatic, aromatic, and heteroaromatic nitriles. Key to this reported procedure is the unprecedented addition of the Grignard reagent to the nitrile under heating by microwave irradiation which both significantly improves reaction yields and reduces reaction times. In general, the Grignard addition reaction is complete within 5-10 min at 100 °C followed by rapid reduction with sodium borohydride to give the target amines.

Substituted imides

Novel imides are inhibitors of tumor necrosis factor α and can be used to combat cachexia, endotoxic shock, and retrovirus replication. A typical embodiment is 2-Phthalimido-3-(3′,4′-dimethoxyphenyl)propane.

Substituted benzhydryl lactamimide derivatives

Novel compounds useful as diuretic agents and anticoagulants are represented by the following formula SPC1 Wherein m is a positive whole integer of from 1 to 3; n is a positive whole integer of from 3 to 7; R and R1 may be the same or different