23737-52-2

Upstream product

• 554-10-9 3-iodo-propane-1,2-diol 
• 67-64-1 acetone 
• 17579-99-6 methyltriphenoxyphosphonium iodide 
• 100-79-8 (R,S)-2,2-dimethyl-1,3-dioxolane-4-methanol 
• 23737-51-1 solketal tosylate 
• 34832-91-2 1,2-O-isopropylideneglyceryl N,N,N'N,-tetraethylphosphorodiamidite 

Downstream Products

• 554-10-9 3-iodo-propane-1,2-diol 
• 138943-65-4 5-(3,4-Dimethoxy-phenyl)-1-(2,2-dimethyl-[1,3]dioxolan-4-yl)-pentan-2-one 
• 22195-47-7 4-aminomethyl-2,2-dimethyl[1,3]dioxolane 
• 792966-26-8 2,2-dimethyl-4-(2-phenylsulfanyl-but-3-enyl)-[1,3]dioxolane 

Relevant academic research and scientific papers

Design and preparation of a novel prolinamide-based organocatalyst for the solvent-free asymmetric aldol reaction

The preparation of four novel organocatalysts as highly diastereo and enantioselective catalysts for the solvent-free asymmetric aldol reaction was described. These organocatalysts were synthesized in eight steps applying simple and commercially available starting materials. The best results were obtained for the proline-derived catalyst, providing access to the desired adducts in up to 95% yield, 1:19 syn/anti and 98% e.e. Moreover, even sterically bulky aldehydes and substituted cyclohexanones were well tolerated. DFT calculations and control experiments indicated that several hydrogen bonding interactions between the aldehyde and the enamine intermediate are responsible for the stereoselective chiral induction process and that the trifluoroacetate counter-anion is crucial for the attainment of higher stereoselectivities.

Amino acid ionic liquids as catalysts in a solvent-free Morita-Baylis-Hillman reaction

In the present work, we describe the preparation of ten amino acid ionic liquids (AAILs) formed from ammonium salts as cations, derivatives of glycerol, and natural amino acids as anions. All of them are viscous oils, colorless or pale yellow, and hygroscopic at room temperature. They have appreciable solubility in many protic and aprotic polar solvents. The AAILs were used as catalysts in a Morita-Baylis-Hillman (MBH) reaction. The ionic liquids derivative from l-proline and l-histidine demonstrated the ability to catalyze the reaction between methyl vinyl ketone and aromatic aldehydes differently substituted in the absence of an additional co-catalyst under organic solvent-free conditions. The AAIL derivatives from l-valine, l-leucine, and l-tyrosine catalyzed the MBH reaction only in the presence of imidazole. The MBH adducts were obtained in moderate to good yields. Although the catalytic site in the ILs was in its enantiomerically pure form, all the MBH adducts were obtained in their racemic form.

Conjugated TLR7 and/or TLR8 and TLR2 polycationic agonists

The present invention relates to a conjugated compound of Formula I : Q-Z-R4 wherein Q is a TLR7 and/or TLR8 agonist and Z-R4 is a TLR2 agonist, said conjugated compound being chosen among compounds of Formula II :

Conjugated TLR7 and/or TLR8 and TLR2 polycationic agonists

A conjugated compound of Formula I: Q-Z—R4 wherein Q is a TLR7 and/or TLR8 agonist and Z—R4 is a TLR2 agonist, the conjugated compound being chosen among compounds of Formula II:

CONJUGATED TLR7 AND/OR TLR8 AND TLR2 AGONISTS

A conjugated compound of formula Q-Z—R4 wherein Q is a TLR7 and/or TLR8 agonist and Z—R4 is a TLR2 agonist, and the uses thereof in the treatment of infection, cancer or immune disorders or for use in vaccines.

A further synthesis of an analogue of the antifungal/antiherbivore lipid from avocado

A further synthesis of the saturated racemic derivative (1b) of the avocado diene (1a) ((R,Z,Z)-2-hydroxy-4-oxohenicosa-12,15-dien-l-yl acetate; 'persin') is described.

Anti-trypanosomal compounds. I. In vivo and in vitro activity of inhibitors of glycolysis in trypanosomes

Carboxylated and phosphorylated esters of glycerol, possible inhibitors of the atypical glycolysis in trypanosomes have been synthesised and tested on Trypanosoma equiperdum in vitro and Trypanosoma brucei, on mice, and some of them also on glycerol phosphate dehydrogenase (GDH).Two of these compounds which showed no in vitro activity behaved as good competitive inhibitors of GDH; 3 other compounds were shown to have a good activity on cultures of trypanosomes, but owing to their weak solubility, tests on the enzyme could not be conclusive.Indications for the design of other compounds have been given.

Reaction of Carbohydrate Halides with Magnesium. Novel C-C Coupling of Sugar Derivatives via Organometallic Intermediates

The reaction of 3-deoxy-3-C-(iodomethyl)-1,2:5,6-di-O-isopropylidene-α-D-allofuranose (1c) with sublimed magnesium in refluxing tetrahydrofuran gave dimer 2 and only traces of the 3-deoxy-3-methyl derivative 1d.Similarly methyl 5-deoxy-5-iodo-2,3-O-isopro