23746-34-1Relevant academic research and scientific papers
A bismuth diethyldithiocarbamate compound promotes apoptosis in HepG2 carcinoma, cell cycle arrest and inhibits cell invasion through modulation of the NF-κB activation pathway
Ishak, Dayang Hazwani Abang,Ooi, Kah Kooi,Ang, Kok-Pian,Akim, Abdah Md,Cheah, Yoke-Kqueen,Nordin, Norshariza,Halim, Siti Nadiah Binti Abdul,Seng, Hoi-Ling,Tiekink, Edward R.T.
, p. 38 - 51 (2014)
The compound with R = CH2CH3 in Bi(S 2CNR2)3 (1) is highly cytotoxic against a range of human carcinoma, whereas that with R = CH2CH2OH (2) is considerably less so. Both 1 and 2 induce apoptosis in HepG2 cells with some evidence for necrosis induced by 2. Based on DNA fragmentation, caspase activities and human apoptosis PCR-array analysis, both the extrinsic and intrinsic pathways of apoptosis have been shown to occur. While both compounds activate mitochondrial and FAS apoptotic pathways, compound 1 was also found to induce another death receptor-dependent pathway by induction of CD40, CD40L and TNF-R1 (p55). Further, 1 highly expressed DAPK1, a tumour suppressor, with concomitant down-regulation of XIAP and NF-κB. Cell cycle arrest at the S and G2/M phases correlates with the inhibition of the growth of HepG2 cells. The cell invasion rate of 2 is 10-fold higher than that of 1, a finding correlated with the down-regulation of survivin and XIAP expression by 1. Compounds 1 and 2 interact with DNA through different binding motifs with 1 interacting with AT- or TA-specific sites followed by inhibition of restriction enzyme digestion; 2 did not interfere with any of the studied restriction enzymes.
Dithiocarbamate copper(I) and silver(I) complexes: Synthesis, structure and thermal behavior
Mothes, Robert,Petzold, Holm,Jakob, Alexander,Rüffer, Tobias,Lang, Heinrich
, p. 227 - 236 (2015)
Complexes [M(PBu3)n(S2CNRR′)] (M = Cu, Ag; n = 1, 2, 3; R = R′ = CH2CHCH2, (CH2)4, C2H4OH; R = Me, R′ = C2H4OH; R = Bu, R′ = C2/
COMPOSITIONS AND METHODS FOR SELECTIVE SEPARATION OF MINERALS FROM SULFIDE ORES
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Paragraph 0168; 0170, (2018/04/20)
Compositions including blends of one or more acrylamide/allyl thiourea polymer as a first depressant, and one or more carboxyalkyl dithiocarbamate compound as a second depressant, and their use as depressants in the beneficiation of sulfide minerals from ores and/or concentrates are disclosed herein, along with methods for selectively separating value sulfide minerals from non-value sulfide minerals in a froth flotation process for the recovery of such value minerals.
