2375-96-4

Usage

Uses

Used in Pharmaceutical Industry:
1,4-bis(trifluoromethyl)-2,5-dibromobenzene is utilized as a building block in the synthesis of pharmaceuticals for its ability to enhance the properties of new drugs. Its trifluoromethyl and bromine substituents are particularly valuable in the development of compounds with improved efficacy and stability.
Used in Agrochemical Industry:
In the agrochemical sector, 1,4-bis(trifluoromethyl)-2,5-dibromobenzene serves as a key intermediate in the production of agrochemicals, where its unique molecular structure can contribute to the creation of more effective and stable pesticides or other agricultural chemicals.
Used in Materials Science:
1,4-bis(trifluoromethyl)-2,5-dibromobenzene is employed in materials science as a component in the development of advanced materials with tailored properties. Its thermal and chemical stability make it a suitable candidate for use in high-performance materials for various applications.
Used as a Reagent in Organic Reactions:
Due to its high thermal and chemical stability, 1,4-bis(trifluoromethyl)-2,5-dibromobenzene is also used as a reagent in various organic reactions, where it can facilitate specific chemical transformations or improve the yield of desired products.

Upstream product

• 433-19-2 1,4-bis(trifluoromethyl)benzene 
• 100-21-0 terephthalic acid 
• 81290-20-2 (trifluoromethyl)trimethylsilane 
• 63262-06-6 1,4-dibromo-2,5-diiodobenzene 

Downstream Products

• 366008-67-5 2,5-bis(trifluoromethyl)terephthalic acid 
• 1084895-79-3 1,4-bis(trimethylsilylethynyl)-2,5-bis(trifluoromethyl)benzene 
• 1073339-16-8 2,2'-(2,5-bis(trifluoromethyl)-1,4-phenylene)bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolane) 
• 1084895-80-6 1,4-diethynyl-2,5-bis(trifluoromethyl)benzene 
• 847450-36-6 1,4-bis(trifluoromethyl)-2,5-dibromomethylbenzene 
• 847450-35-5 (4-hydroxymethyl-2,5-bis-trifluoromethyl-phenyl)-methanol 

Relevant academic research and scientific papers

Adsorption of Fluorocarbons and Chlorocarbons by Highly Porous and Robust Fluorinated Zirconium Metal-Organic Frameworks

Fluorocarbons and chlorocarbons are common volatile organic compounds that pose serious risk to the environment and human health and therefore need to be effectively captured. Herein, we report a series of highly fluorinated metal-organic frameworks with high porosity (Brunauer-Emmett-Teller surface area 3000 m2/g) and stability. They show exceptionally high capacity and good recyclability toward the adsorption of fluorocarbons and chlorocarbons.

Trifluoromethyl-substituted conjugated oligoelectrolytes

Conjugated oligoelectrolytes (COEs) are being introduced into a variety of optical and electronic technologies, yet the dependence of their properties as a function of molecular structure remains poorly understood. In response, we designed, synthesized, and examined a new tetracationic COE, namely, 1,4-bis{9′,9′-bis[6″-(N,N,N-trimethylammonium)hexyl] -2′-fluorenyl)-2,5-bis(trifluoromethyl)benzene tetrabromide (FPF-F6), which contains bulky electron-withdrawing trifluoromethyl groups, and compared its properties with the unsubstituted counterpart 1,4-bis{9′,9′- bis[6″-(N,N,N-trimethylammonium)hexyl]-2′-fluorenyl}benzene tetrabromide (FPF). The groundstate geometry of FPF-F6 is primarily twisted with little electronic communication between the aromatic units, as confirmed by single-crystal X-ray diffraction studies of the neutral precursor. However, absorption and photoluminescence spectroscopies reveal that the excited state of FPF-F6 displays strong intramolecular charge-transfer characteristics. Solution AFM in aqueous media shows that introduction of trifluoromethyl groups changes the size and aspect ratio of supramolecular aggregates that are brought together as a result of hydrophobic interactions. Furthermore, addition of ssDNA to FPFF6 leads to interoligoelectrolyte complexes wherein the backbone is more planar; the environment the chromophore experiences under these conditions is also considerably less polar. These findings provide considerable insight into the complex photophysics of electronically conjugated materials in aqueous media.

A new polymer with low dielectric constant based on trifluoromethyl-substituted arene: Preparation and properties

A new polymer with low dielectric constant is reported here. This polymer contains a trifluoromethyl-substituted phenyl unit and a binaphthyl unit, and shows high thermostability with a glass transition temperature of 244 °C and a 5 wt% loss at temperature 518 °C under nitrogen. The polymer also exhibits good film-forming ability, and the formed films exhibit high hydrophobicity with a contact angle of 103.6° with water. In a range of frequencies from 1 to 25 MHz, the polymer reveals an average dielectric constants of about 2.56. In regard to the mechanical properties, the polymer film shows an average hardness of 0.37 GPa and a Young's modulus of 15.07 GPa. These results indicate that the polymer could be used as a varnish for enameled wire, sizing agents for high-performance carbon fiber, and the matrix resin for the production of laminated composites utilized in the printed-circuit-board (PCB) industry. This journal is

Ultra-photostable n-type PPVs

Poly(p-phenylenevinylene)s containing trifluoromethyl substituted aromatic rings (CFS-PPVs) exhibit high photooxidative stability to give robust materials suitable for demanding applications.

Precisely embedding active sites into a mesoporous Zr-framework through linker installation for high-efficiency photocatalysis

The pore engineering of microporous metal-organic frameworks (MOFs) has been extensively investigated in the past two decades, and an expansive library of functional groups has been introduced into various frameworks. However, the reliable procurement of MOFs possessing both a targeted pore size and preferred functionality together is less common. This is especially important since the applicability of many elaborately designed materials is often restricted by the small pore sizes of microporous frameworks. Herein, we designed and synthesized a mesoporous MOF based on Zr6 clusters and tetratopic carboxylate ligands, termed PCN-808. The accessible coordinatively unsaturated metal sites as well as the intrinsic flexibility of the framework make PCN-808 a prime scaffold for postsynthetic modification via linker installation. A linear ruthenium-based metalloligand was successfully and precisely installed into the walls of open channels in PCN-808 while maintaining the mesoporosity of the framework. The photocatalytic activity of the obtained material, PCN-808-BDBR, was examined in the aza-Henry reaction and demonstrated high conversion yields after six catalytic cycles. Furthermore, thanks to the mesoporous nature of the framework, PCN-808-BDBR also exhibits exceptional yields for the photocatalytic oxidation of dihydroartemisinic acid to artemisinin.

SUBSTITUTED BIS(TRIFLUOROVINYL)BENZENE COMPOUND

There is provided a substituted bis(trifluorovinyl)benzene compound that is excellent in heat stability and is industrially useful, and a method for producing the same. There are used a substituted bis(trifluorovinyl)benzene compound represented by genera

Functionalization in flexible porous solids: Effects on the pore opening and the host-guest interactions

The synthesis on the gram scale and characterization of a series of flexible functionalized iron terephthalate MIL-53(Fe) type solids are reported. Chemical groups of various polarities, hydrophilicities, and acidities (-Cl, -Br, -CF3, -CH3, -NH2, -OH, -CO2H) were introduced through the aromatic linker, to systematically modify the pore surface. X-ray powder diffraction (XRPD), molecular simulations, thermogravimetric analyses, and in situ IR and 57Fe Moessbauer spectrometries indicate some similarities with the pristine MIL-53(Fe) solid, with the adoption of the narrow pore form for all solids in both the hydrated and dry forms. Combined XRPD and computational structure determinations allow concluding that the geometry of the pore opening is predominantly correlated with the intraframework interactions rather than the steric hindrance of the substituent. Only (MIL-53(Fe)-(CF3)2) exhibits a nitrogen accessible porosity (SBET ≈ 100 m2 g-1). The adsorption of some liquids leads to pore openings showing some very specific behaviors depending on the guest-MIL-53(Fe) framework interactions, which can be related to the energy difference between the narrow and large pore forms evaluated by molecular simulation.

ORGANIC/INORGANIC HYBRID NANOPARTICULATES MADE FROM IRON CARBOXYLATES

The invention relates to nanoparticles made from organometallic hybrid materials made from iron carboxylates, used for example as contrast agents. The particles can also be used for the encapsulation and vectoring of molecules of interest such as active3 pharmaceutical agents, cosmetically interesting compounds and markers. Apart from the intrinsic properties thereof for imaging, said nanoparticles give good results in terms of capacity for loading with medicaments and in biocompatibility.

Poly(pyridinium phenylene)s: Water-soluble N-type polymers

(Chemical Equation Presented) Poly(pyridinium phenylene) conjugated polymers are synthesized by a cross-coupling and cyclization sequence. These polyelectrolytes are freely soluble in water and display high degrees of electroactivity. When reduced (n-doped) these materials display in situ conductivities as high as 160 S/cm. The high conductivity is attributed to the planar structure that is enforced by the cyclic structures of the polymer. The electron affinities are compared to PCBM, a C60 based n-type material. We find that these polymers undergo excited state electron transfer reactions with other donor conjugated polymers and hence may find utility in photovoltaic devices.

A convenient new method for the bromination of deactivated aromatic compounds

Treatment of deactivated aromatic compounds with N-bromosuccinimide in trifluoroacetic acid solvent in the presence of sulfuric acid gave the corresponding monobromoaromatic compounds in good to excellent yields.