23761-27-5Relevant academic research and scientific papers
Difluoro-Substituted Bicyclo[1.1.1]pentanes for Medicinal Chemistry: Design, Synthesis, and Characterization
Bychek, Roman M.,Hutskalova, Valeriia,Bas, Yuliya P.,Zaporozhets, Olga A.,Zozulya, Sergey,Levterov, Vadym V.,Mykhailiuk, Pavel K.
, p. 15106 - 15117 (2019/10/17)
A practical synthetic approach to the difluoro-substituted bicyclo[1.1.1]pentanes was developed. The key step was an addition of difluorocarbene (:CF2) to electron-rich bicyclo[1.1.0]butanes by the CF3TMS/NaI system. The obtained dif
A Selective Synthesis of 2,2-Difluorobicyclo[1.1.1]pentane Analogues: "BCP-F2"
Ma, Xiaoshen,Sloman, David L.,Han, Yongxin,Bennett, David J.
supporting information, p. 7199 - 7203 (2019/10/08)
The bicyclo[1.1.1]pentane (BCP) motif has been utilized as bioisosteres in drug candidates to replace phenyl, tert-butyl, and alkynyl fragments in order to improve physicochemical properties. However, bceause of the difficulty of synthesis, most BCP analo
