30493-91-5Relevant academic research and scientific papers
Difluoro-Substituted Bicyclo[1.1.1]pentanes for Medicinal Chemistry: Design, Synthesis, and Characterization
Bychek, Roman M.,Hutskalova, Valeriia,Bas, Yuliya P.,Zaporozhets, Olga A.,Zozulya, Sergey,Levterov, Vadym V.,Mykhailiuk, Pavel K.
, p. 15106 - 15117 (2019)
A practical synthetic approach to the difluoro-substituted bicyclo[1.1.1]pentanes was developed. The key step was an addition of difluorocarbene (:CF2) to electron-rich bicyclo[1.1.0]butanes by the CF3TMS/NaI system. The obtained dif
