23766-14-5

Upstream product

• 93034-60-7 1-[(4′-chlorophenyl)carbonyl-4-phenyl]thiosemicarbazide 
• 50906-25-7 1-(4-chloro-benzoyl)-4-phenyl-semicarbazide 
• 113246-33-6 N-[5-(4-Chloro-phenyl)-[1,3,4]oxadiazol-2-yl]-N-phenyl-N'-[1-phenyl-meth-(Z)-ylidene]-hydrazine 
• 5351-69-9 4-Phenyl-3-thiosemicarbazide 
• 74-11-3 para-chlorobenzoic acid 
• 16687-61-9 5-(4-chlorophenyl)-1H-tetrazole 
• 103-71-9 phenyl isocyanate 
• 23767-27-3 N'-(4-chloro-benzoyl)-hydrazinecarboxylic acid ethyl ester 
• 16687-61-9 5-(4-chlorophenyl)tetrazole 
• 113246-30-3 5-(4-Chloro-phenyl)-tetrazole-2-carboxylic acid N-phenyl-N'-[1-phenyl-meth-(E)-ylidene]-hydrazide 
• 52185-41-8 benzaldehyde 2-chloroformyl-2-phenylhydrazone 
• 536-40-3 4-chlorobenzoic acid hydrazide 
• 103-72-0 phenyl isothiocyanate 

Downstream Products

• 32380-22-6 N-[5-(4-chloro-phenyl)-[1,3,4]oxadiazol-2-yl]-N-phenyl-acetamide 
• 32380-17-9 N-(4-bromophenyl)-5-(4-chlorophenyl)-2-amino-1,3,4-oxadiazole 

Relevant academic research and scientific papers

Discovery of novel GSK-3β inhibitors with potent in vitro and in Vivo activities and excellent brain permeability using combined ligand- and structure-based virtual screening

Dysregulation of glycogen synthase kinase (GSK-3β) is implicated in the pathophysiology of many diseases, including type-2 diabetes, stroke, Alzheimers, and others. A multistage virtual screening strategy designed so as to overcome known caveats arising from the considerable flexibility of GSK-3β yielded, from among compounds in our in-house database and two commercial databases, new GSK-3β inhibitors with novel scaffold structures. The two most potent and selective validated hits, a 2-anilino-5-phenyl-1,3,4- oxadiazole (24) and a phenylmethylene hydantoin (28), both exhibited nanomolar affinity and selectivity over CDK2 and were potent enough for direct in vivo validation. Both were able to cause significant increases in liver glycogen accumulation in dose-dependent fashion. One also exhibited excellent blood-brain barrier permeability, the other adequate for a lead compound. Analogues of the oxadiazole 24 were synthesized to experimentally corroborate or rule out ligand-bound structures arising from docking studies. SAR results supported one docking study among a number of alternatives.

Tetrazoles: LV. Perparation of 2-anilino-5-aryl(hetaryl)-1,3,4-oxadiazoles from 5-substituted tetrazoles under microwave activation

In reaction of 5-aryl(hetaryl)tetrazoles with phenyl isocyanate under the conditions of microwave activation the corresponding 2-anilino-5-aryl(hetaryl)- 1,3,4-oxadiazoles formed in high yields. The application of the microwave activation fourfold reduced

15N NMR study of substituted 2-(phenylamino)-5-phenyl-1,3,4- oxadiazoles

Substituted 2-(phenylamino)-5-phenyl-1,3,4-oxadiazoles were studied by 15N NMR spectroscopy. All signals were assigned on the basis of HMQC and HMBC experiments. Chemical shifts values were correlated with empirical Hammett parameters as well a

Fragmentation and skeletal rearrangements of 2-arylylamino-5-aryl-1,3,4- oxadiazoles and their noncovalent complexes with cobalt cation and cyclodextrin studied by mass spectrometry

Mass spectrometric fragmentation pathways of title compounds were studied by electron ionization (EI) and electrospray ionization (ESI) as methods of ion generation. To explain the observed complex skeletal rearrangements, tandem mass spectrometry, accurate mass measurement and isotope labeling (compounds containing one 13C atom in oxadiazole ring) were used. Loss of CO, N2 and H atoms under EI conditions led to the formation of 9,10-dihydroacridine-type ions, loss of NH3 under ESI conditions yielded the 4-phenylphthalazinone-type ions and the loss of HNCO under ESI conditions produced N-arylamino-benzonitrilium ions; however, this process can be affected by the electron-donor/electron-withdrawing properties of groups substituted at the phenyl rings. The ESI was used to study the complexes of the compounds with cobalt as well as with cyclodextrin. It was found that the compounds studied tend to form inclusion complexes with cyclodextrin of stoichiometry 1:1 and complexes of different stoichiometries with cobalt, although those of stoichiometry 6:1 and 4:1 are favored and the attachment of counter ion may stabilize the complexes 3:1 and 2:1. Copyright

Thermal Ring Transformation of 5-Aryl-2-carbazoyl-1,2,3,4-tetrazole Derivatives

Unstable 5-aryl-2-(3-benzylidene-2-phenylcarbazoyl)-1,2,3,4-tetrazoles 8 have been prepared.By thermal ring transformation, they gave 5-aryl-2-(2-benzylidene-1-phenylhydrazino)-1,3,4-oxadiazoles 9.Hydrazinolysis of 9 afforded 5-aryl-2-(1-phenylhydrazino)-