23767-27-3

Upstream product

• 4231-70-3 p-chlorobenzoyl-1H-1,2,3-benzotriazole 
• 4114-31-2 ethylhydrazine carboxylate 
• 74-11-3 para-chlorobenzoic acid 
• 541-41-3 chloroformic acid ethyl ester 
• 536-40-3 4-chlorobenzoic acid hydrazide 

Downstream Products

• 3206-34-6 2-(4-chlorophenyl)-5-ethoxy-1,3,4-oxadiazole 
• 1711-61-1 5-(4-chlorophenyl)-3H-[1,3,4]oxadiazol-2-one 
• 23766-15-6 benzyl-[5-(4-chloro-phenyl)-[1,3,4]oxadiazol-2-yl]-amine 
• 23766-14-5 2-anilino-5-(4-chlorophenyl)-1,3,4-oxadiazole 
• 90736-28-0 2-chloro-5-(4-chloro-phenyl)-[1,3,4]oxadiazole 

Relevant academic research and scientific papers

Synthesis and In Vitro Anticancer Activity of Novel 1,3,4-Oxadiazole-Linked 1,2,3-Triazole/Isoxazole Hybrids

A series of new 1,3,4-oxadiazole-linked 1,2,3-triazole/isoxazole derivatives were designed and synthesized. All the synthesized compounds were screened for in vitro anticancer activity against four human cancer cells: HeLa (cervical), MDA-MB-231 (breast), DU-145 (prostate), and HEPG2 (liver). Among 17 compounds tested, 7a, 7c, and 7d showed potent activity toward four cell lines.

Application of N-Acylbenzotriazoles in the Synthesis of 5-Substituted 2-Ethoxy-1,3,4-oxadiazoles as Building Blocks toward 3,5-Disubstituted 1,3,4-Oxadiazol-2(3H)-ones

5-Substituted-2-ethoxy-1,3,4-oxadiazoles were conveniently prepared through a one-pot sequential N-acylation/dehydrative cyclization between ethyl carbazate and N-acylbenzotriazoles in the presence of Ph3P-I2 as a dehydrating agent. Subsequent treatment with a stoichiometric amount of alkyl halides (X = Cl, Br, I) enables a rapid access to a variety of 3,5-disubstituted 1,3,4-oxadiazol-2(3H)-ones in good to excellent yields.