23767-72-8

Upstream product

• 1885-23-0 dibromomalononitrile 
• 123-11-5 4-methoxy-benzaldehyde 
• 2826-26-8 2-(4-methoxyphenylmethylene)malononitrile 
• 109-77-3 malononitrile 
• 506-68-3 bromocyane 

Relevant academic research and scientific papers

Synthesis of 3-Arylcyclopropane-1,1,2,2-tetracarbonitriles under Micellar Catalysis

An environmentally benign procedure has been developed for the synthesis of 3-arylcyclopropane- 1,1,2,2-tetracarbonitriles in an aqueous surfactant solution.

Solvent-free, one-pot synthesis of pentasubstituted cyclopropanes in the presence of BrCN and EtONa by milling

A solvent-free, one-pot process for the preparation of pentasubstituted 3-arylcyclopropane-1,1,2,2-tetracarbonitriles in the presence of solid sodium ethoxide by milling was achieved. The one-pot reaction of aromatic aldehydes and dialdehydes with malonon

Flash preparation of carbenoids: A different performance of cyanogen bromide

Cyanogen halides are known substances for the cyanating reaction. There are a few evidences for bromination reaction too. On the other hand carbenes are known as very important substances due to their remarkable reactions. Unfortunately carbenes at room temperature are very unstable and there is not a simple method for preparation of them. In most cases the isolation is not possible. We have reported a new reliable and fast preparation method of almost stable carbenoids. The mechanism of the formation has been discussed.

A new, fast and easy strategy for one-pot synthesis of full substituted cyclopropanes: Direct transformation of aldehydes to 3-aryl-1,1,2,2- tetracyanocyclopropanes

A new, fast and easy method for one-pot reaction of aromatic aldehydes and dialdehydes with malononitrile and cyanogen bromide has been developed to afford full substituted 3-arylcyclopropane-1,1,2,2-tetracarbonitriles in excellent yields in very short time (about 5 seconds). The structures elucidations were characterized by IR, 1H NMR, 13C NMR, mass spectrometry and X-ray crystallography techniques. For these compounds the crystallographic data showed two structures in mirror image in solid case and one distinct structure in solution. The reaction mechanism was discussed.

A new type of cascade reaction: direct conversion of carbonyl compounds and malononitrile into substituted tetracyanocyclopropanes

A new type of chemical cascade reaction was found: the direct formation of cyclopropanes from carbonyl compounds and C-H acid. The action of free halogen or active halogen containing compounds on a mixture of 1 equiv of carbonyl compound and 2 equiv of malononitrile in a basic alcohol solution results in the formation of substituted 1,1,2,2-tetracyanocyclopropanes in 15-80% yield. The latter are well-known precursors for the different bicyclic heterosystems, among them compounds containing a cyclopropane ring and possessing different types of pharmacological activity. Thus, the new, simple and efficient 'one-pot' way to substituted tetracyanocyclopropanes in 50-80% yield was found directly from such simple and reasonable starting compounds as aldehydes, or some cyclic ketones, or substituted cyclohexanones and malononitrile.

One-pot cascade assembling of 3-substituted tetracyanocyclopropanes from alkylidenemalononitriles and malononitrile by the only bromine direct action

The new cascade reaction was found: the formation of cyclopropanes from alkylidenemalononitriles and malononitrile by the only bromine direct action; the action of aqueous bromine on the equal amounts of alkylidenemalononitriles and malononitrile in EtOH-

A new strategy of the chemical route to the cyclopropane structure: direct transformation of benzylidenemalononitriles and malononitrile into 1,1,2,2-tetracyanocyclopropanes

The new reaction was found: the direct formation of cyclopropanes from activated olefins and C-H acids. The action of free halogen or active halogen containing compounds on the equal amounts of benzylidenemalononitriles and malononitrile in basic alcohol

Cyclopropanation of Electron-deficient Alkenes and Wideqvist-type Synthesis of Cyclopropanes mediated by Indium Metal

Cyclopropanation of electron-deficient alkenes and Wideqvist-type transformation of carbonyl compounds to cyclopropanes have been achieved by the action of active methylene dibromides and metallic indium.