854778-26-0

Basic information

• Product Name: 3-Bromo-4-hydroxy-8-trifluoromethylquinoline
• Synonyms: 3-Bromo-4-hydroxy-8-trifluoromethylquinoline;3-bromo-8-(trifluoromethyl)-4-Quinolinol;3-Bromo-8-trifluoromethyl-1H-quinolin-4-one
• CAS NO: 854778-26-0
• Molecular Formula: C₁₀H₅BrF₃NO
• Molecular Weight: 292.0520096
• Mol File: 854778-26-0.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 312.8°C at 760 mmHg
• Flash Point: 143°C
• Appearance: /
• Density: 1.771g/cm³
• Vapor Pressure: 0.000282mmHg at 25°C
• Refractive Index: 1.604
• CAS DataBase Reference: 3-Bromo-4-hydroxy-8-trifluoromethylquinoline(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Bromo-4-hydroxy-8-trifluoromethylquinoline(854778-26-0)
• EPA Substance Registry System: 3-Bromo-4-hydroxy-8-trifluoromethylquinoline(854778-26-0)

Safety Data

• Hazardous Substances Data: 854778-26-0(Hazardous Substances Data)

Usage

InChI:InChI=1/C10H5BrF3NO/c11-7-4-15-8-5(9(7)16)2-1-3-6(8)10(12,13)14/h1-4H,(H,15,16)

Upstream product

• 23779-96-6 4-hydroxy-8-trifluoromethylquinoline 
• 23851-84-5 4-hydroxy-8-trifluoromethyl-quinoline-3-carboxylic acid ethyl ester 
• 23779-95-5 4-hydroxy-8-(trifluoromethyl)quinoline-3-carboxylic acid 
• 23779-94-4 2-[(2-trifluoromethylphenylamino)methylene]malonic acid diethyl ester 
• 88-17-5 2-(trifluoromethyl)benzenamine 

Downstream Products

• 854775-30-7 methyl {4-[({3-[3-phenyl-8-(trifluoromethyl)quinolin-4-yl]phenyl}amino)methyl]phenyl}acetate 
• 854769-68-9 {3-[3-phenyl-8-(trifluoromethyl)quinolin-4-yl]phenyl}amine 
• 854778-28-2 4-bromo-3-phenyl-8-(trifluoromethyl)quinoline 
• 854778-27-1 3-phenyl-8-(trifluoromethyl)quinolin-4-ol 

Relevant articles and documents

Click chemistry approach: Regioselective one-pot synthesis of some new 8-trifluoromethylquinoline based 1,2,3-triazoles as potent antimicrobial agents

Three series of 8-trifluoromethylquinoline based 1,2,3-triazoles derivatives (5a-c, 6a-d and 7a-c) were synthesized by multi-step reactions by click chemistry approach. Synthesized compounds were characterized by spectral studies and X-ray analysis. The final compounds were screened for their in-vitro antimicrobial activity by well plate method (zone of inhibition). Compounds 5c, 6b, 8b, 11 and 12 were found to be active against tested microbial strains. The results are summarized in Tables 5 and 6.