23838-70-2

Basic information

• Product Name: 3-(4-HYDROXYPHENYL)PROPIONAMIDE
• Synonyms: PHORETAMIDE;PHLORETAMIDE;3-(4-HYDROXYPHENYL)PROPIONAMIDE;3-(4-hydroxyphenyl)propanamide
• CAS NO: 23838-70-2
• Molecular Formula: C₉H₁₁NO₂
• Molecular Weight: 165.19
• Product Categories: Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts
• Mol File: 23838-70-2.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 424.8°Cat760mmHg
• Flash Point: 210.7°C
• Appearance: /
• Density: 1.197g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.579
• CAS DataBase Reference: 3-(4-HYDROXYPHENYL)PROPIONAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(4-HYDROXYPHENYL)PROPIONAMIDE(23838-70-2)
• EPA Substance Registry System: 3-(4-HYDROXYPHENYL)PROPIONAMIDE(23838-70-2)

Safety Data

• Hazardous Substances Data: 23838-70-2(Hazardous Substances Data)

Usage

General Description

3-(4-Hydroxyphenyl)propionamide is a chemical compound and an amide derivative of 4-hydroxyphenylpropionic acid. It is commonly used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. This chemical is also known for its antioxidant and anti-inflammatory properties, making it potentially useful in the development of new drugs for treating various diseases and conditions. The compound is typically produced through chemical synthesis and is not naturally occurring, and it is important for researchers and manufacturers to adhere to safety guidelines when handling and using this substance in laboratory settings.

InChI:InChI=1/C9H11NO2/c10-9(12)6-3-7-1-4-8(11)5-2-7/h1-2,4-5,11H,3,6H2,(H2,10,12)

Upstream product

• 23795-02-0 3-(4-hydroxy-phenyl)-propionic acid ethyl ester 
• 194940-15-3 4-hydroxycinnamic acid amide 
• 35666-07-0 C₁₅H₁₃NO₅ 
• 501-97-3 4-hydroxyphenylpropionic acid 
• 83351-75-1 tert-butyl (S)-(1-amino-3-(4-hydroxyphenyl)-1-oxopropan-2-yl)carbamate 
• 5597-50-2 3-(4-hydroxyphenyl)propionic acid methyl ester 

Downstream Products

• 1044921-33-6 2-(4-Hydroxycyclohexyl)propansaeureamid 
• 501-97-3 4-hydroxyphenylpropionic acid 
• 649740-41-0 3-[4-(3,4-difluoro-benzyloxy)-phenyl]-propionamide 
• 29112-44-5 3-[3-Allyl-4-(2-hydroxy-3-isopropylamino-propoxy)-phenyl]-propionamide 
• 950186-11-5 3-(4-acetoxyphenyl)propanenitrile 
• 60-82-2 3-(4-Hydroxy-phenyl)-1-(2,4,6-trihydroxy-phenyl)-propan-1-on 
• 17362-17-3 3-(p-hydroxyphenyl)propiononitrile 
• 116941-22-1 trans-2-(4-Acetyloxycyclohexyl)propionitril 
• 29112-57-0 3-(4-Allyloxy-phenyl)-propionamide 
• 10210-17-0 3-(4-hydroxyphenyl)propan-1-ol 
• 51-67-2 tyrosamine 

Relevant articles and documents

A 3 - (4-hydroxy phenyl) propionamide synthetic method

The invention discloses a synthesis method of 3-(4-hydroxyphenyl)propanamide. P-hydroxyphenylpropionic acid used as the raw material is subjected to continuous two-step reaction to prepare the 3-(4-hydroxyphenyl)propanamide. The reaction system composed o

Sinapis phylogeny and evolution of glucosinolates and specific nitrile degrading enzymes

Levels of sinalbin (4-hydroxybenzylglucosinolate) and 28 other glucosinolates were determined in leaves and roots of 20 species that were either phylogenetically close to Sinapis alba, Sinapis arvensis, or Sinapis pubescens (tribe Brassiceae, Brassicaceae), or were expected to contain arylalkyl nitrilase activity. Comparison with a molecular phylogenetic tree based on ITS DNA sequences identified two separate occurrences of sinalbin. The first in a group of species related to S. alba (including members of the genera Coincya and Kremeriella); and the second in S. arvensis, nested among sinalbin deficient species. Significant 4-hydroxyphenylacetonitrile degrading enzyme activity was found in both S. alba and S. arvensis, but in S. alba the major product was the corresponding carboxylic acid, while in S. arvensis the major product was the amide. Both investigated enzyme activities, nitrilase and nitrile hydratase, were specific, accepting only certain arylacetonitriles such as 4-hydroxy and 4-methoxyphenylacetonitrile. Only the S. alba enzyme required an oxygen in para position of the substrate, as found in sinalbin. Indole-3-acetonitrile, arylcyanides, and arylpropionitriles were poor substrates. The nitrilase activity of S. alba was quantitatively comparable to that reported in the monocot Sorghum bicolor (believed to be involved in cyanogenic glycoside metabolism). Glucosinolates derived from methionine were found in all Sinapis clades. Glucosinolate patterns suggested a complex evolution of glucosinolates in the investigated species, with several apparent examples of abrupt changes in glucosinolate profiles including chain length variation and appearance of glucosinolates derived from branched-chain amino acids. NMR data for desulfated homosinalbin, 9-methylsulphonylnonylglucosinolate, 3-methylpentylglucosinolate and related glucosinolates are reported, and a facultative connection between sinalbin and specific nitrilases is suggested.

RECEPTOR FUNCTION CONTROLLING AGENT

The GPR40 receptor function regulator of the present invention, which comprises a compound having an aromatic ring and a group capable of releasing cation is useful as an insulin secretagogue or an agent for the prophylaxis or treatment of diabetes and the like.