23848-96-6Relevant academic research and scientific papers
CYCLOPROPYLAMINE DERIVATIVES USEFUL AS INHIBITORS OF HISTONE DEMETHYLASES KDM1A
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Page/Page column 101, (2014/06/24)
(I) The present invention relates to cyclopropyl derivatives of general formula (I), wherein A, R1, and R2 are as defined in the specification. The present application also relates to pharmaceutical compositions containing such compounds and to their use in therapy.
Substituent position-driven reaction pathways in the heterogeneous one-pot reduction/asymmetric hydrogenation of nitro-substituted (E)-2,3- diphenylpropenoic acids over Pd catalyst
Szoelloesi, Gyoergy,Bartok, Mihaly
, p. 16 - 27 (2012/03/11)
The reaction pathway in the heterogeneous enantioselective hydrogenation of nitro-substituted (E)-2,3-diphenylpropenoic acids over Pd catalyst modified by cinchonidine is determined by the position of the substituent. The reaction route was indicated by the H2 consumption curve and enantioselectivity of the final amino acid or 3-phenyl-1,2,3,4-tetrahydro-2- quinolone formed by intramolecular amidation. The obtained enantioselectivities were low with the exception of acids bearing nitro substituent in para position on the 3-phenyl moiety, the latter resulting in good, up to 80 % optical purity. The present study is the first to report the enantioselective heterogeneous catalytic preparation of 1,2,3,4-tetrahydro-2-quinolones and presents an attractive method for obtaining optically enriched 3-(4-aminophenyl)-2- phenylpropionic acids. ARKAT-USA, Inc.
Triethylamine-induced Reactions of Methyl 2,3-Dibromo-2,3-diarylpropanoates in Methanol
Badajoz, Mercedes A.,Montani, Rosana S.,Cabaleiro, Mercedes C.
, p. 124 - 125 (2007/10/03)
The title compounds undergo elimination with methanolic triethylamine to afford the corresponding debrominated olefins, most of them through an E2 stereoconvergent process.
Methyl 2,3-dibromo-2,3-diarylpropanoates. Debromination and dehydrobromination reactions
Badajoz, Mercedes A.,Montant, Rosana S.,Cabaleiro, Mercedes C.
, p. 1717 - 1722 (2007/10/03)
Rate and product studies of the iodide- and methoxide-mediated reactions of methyl (R,R)- and (R,S)-2,3-dibromo-2,3-diarylpropanoates and some of their 2- and 3-(4-substitutedphenyl)-derivatives have been carried out. The results indicate that the reactio
