23853-59-0Relevant articles and documents
Derivatives of 2-(dipropylamino)tetralin: Effect of the C8-substituent on the interaction with 5-HT(1A) receptors
Liu,Yu,Svensson,Cortizo,Lewander,Hacksell
, p. 4221 - 4229 (2007/10/02)
A series of 2-(dipropylamino)tetralin derivatives in which the C8 substituent is varied has been prepared and evaluated pharmacologically to explore the importance of the C8 substituent in the interaction of 2- aminotetralin-based ligands with serotonin (
Comparison of Biological Effects of N-Alkylated Congeners of β-Phenylethylamine Derived from 2-Aminotetralin, 2-Aminoindan, and 6-Aminobenzocycloheptene
Cannon, Joseph G.,Perez, Julio A.,Pease, Jonathan P,Long, John Paul,Flynn, Jan R.,et al.
, p. 745 - 749 (2007/10/02)
Three series of bicyclic, semirigid congeners of β-phenethylamine have been prepared for evaluation of the effect of ring size (and of concomitant conformational variation) on biological activity in a variety of assays for adrenergic and dopaminergic actions.Pharmacologic activity was associated with 2-aminotetralin and 2-aminoindan derivatives, but was not found with 6-aminobenzocycloheptene derivatives.Noteworthy is the ability of several aminotetralins and aminoindans to increase the hot-plate reaction time without eliciting dopaminergic effects.This action was not blocked by pretreatment with naloxone.
The reductive amination of polynuclear aromatic hydrocarbons. A side reaction of the birch reduction.
Bensal,Eisenbraun,Flanagan
, p. 1837 - 1839 (2007/10/04)
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