23853-59-0

Usage

InChI:InChI=1/C16H25N/c1-3-11-17(12-4-2)16-10-9-14-7-5-6-8-15(14)13-16/h5-8,16H,3-4,9-13H2,1-2H3

Upstream product

• 81185-08-2 N-propyl-N-(1,2,3,4-tetrahydro-[2]naphthyl)-propionamide 
• 3955-82-6 (+/-)-8-methoxy-2-(N-propylpropionamido)-1,2,3,4-tetrahydronaphthaline 
• 2954-50-9 2-aminotetralin 
• 802294-64-0 propionic acid 
• 142-84-7 di-n-propylamine 
• 530-93-8 1,2,3,4-tetrahydronaphthalen-2-one 
• 87394-71-6 8-methoxy-2-propylaminotetralin hydrochloride 
• 78950-78-4 8-hydroxy-2-(di-N-propylamino)tetralin 
• 91-20-3 naphthalene 
• 134394-05-1 (+/-)-2-(dipropylaminoZ)-8-<(trifluoromethylsulfonyl)oxy>tetralin 

Relevant academic research and scientific papers

Derivatives of 2-(dipropylamino)tetralin: Effect of the C8-substituent on the interaction with 5-HT(1A) receptors

A series of 2-(dipropylamino)tetralin derivatives in which the C8 substituent is varied has been prepared and evaluated pharmacologically to explore the importance of the C8 substituent in the interaction of 2- aminotetralin-based ligands with serotonin (

Tricarbonylchromium Complexes of 2-Aminotetralin Derivatives. Hydride Displacement of Aromatic Methoxy Groups

Tricarbonylchromium complexes of methoxy-substituted 2-propionamido- and 2-aminotetralins have been prepared and the stereochemistry of (2S)-endo-tricarbonylchromium, (2S)-endo-4c, has been established by X-ray

Comparison of Biological Effects of N-Alkylated Congeners of β-Phenylethylamine Derived from 2-Aminotetralin, 2-Aminoindan, and 6-Aminobenzocycloheptene

Three series of bicyclic, semirigid congeners of β-phenethylamine have been prepared for evaluation of the effect of ring size (and of concomitant conformational variation) on biological activity in a variety of assays for adrenergic and dopaminergic actions.Pharmacologic activity was associated with 2-aminotetralin and 2-aminoindan derivatives, but was not found with 6-aminobenzocycloheptene derivatives.Noteworthy is the ability of several aminotetralins and aminoindans to increase the hot-plate reaction time without eliciting dopaminergic effects.This action was not blocked by pretreatment with naloxone.

Synthesis and pharmacology of some 2 aminotetralins. Dopamine receptor agonists

A series of 2 amino 1,2,3,4 tetrahydronaphthalene compounds bearing substituents on the nitrogen and in the aromatic ring was synthesized from β tetralone intermediates. Compounds were screened in vivo for dopaminergic activity using tests in which apomorphine was especially active. It was found that apparent dopaminergic activity is inherent in 2 dialkylaminotetralins, the dipropylamine substitution being the most consistently productive amine group studied. Activity was greatly enhanced by proper substitution in the aromatic ring. The 5,6 dihydroxy group was the best potentiating group found. These data support the idea that the extended conformation for the phenylethylamine moiety of apomorphine and dopamine is favorable for dopaminergic agonist activity. They also suggest that an unetherified catechol group may not be essential for such activity.