23853-68-1Relevant academic research and scientific papers
FeCl3-Catalyzed Regio-Divergent Carbosulfenylation of Unactivated Alkenes: Construction of a Medium-Sized Ring
Lv, Leiyang,Li, Zhiping
, p. 10985 - 10994 (2018/09/06)
A FeCl3-catalyzed regio-divergent carbosulfenylation of unactivated alkenes with electrophilic N-sulfenophthalimides has been developed. This protocol provides a straightforward and efficient access to various medium-sized rings, especially strained 7- and 8-membered carborings with a sulfur atom attached. The endo/exo selectivity in the reaction depends on the atom number of the chain between arene and alkene. Broad substrate scope, high yields, and gram-scale synthesis exemplified the utility and practicability of this protocol. In addition, this methodology can be extended to the carboselenylation of isolated alkenes.
Highly stereoselective Friedel-Crafts alkylations of unactivated benzenes by episulfonium ion cyclizations
Branchaud, Bruce P,Blanchette, Heather S
, p. 351 - 353 (2007/10/03)
Intermolecular additions of highly enantiomerically enriched episulfonium ions onto activated benzene rings are known to accomplish chiral Friedel-Crafts alkylations. Unactivated benzenes are either unreactive or can give low stereoselectivities. Intramol
