23864-94-0

Upstream product

• 57591-00-1 α-(4-chlorophenyl)-1,2-benzenedimethanol 
• 34824-58-3 2-(2-bromophenyl)-1,3-dioxolan 
• 1447932-28-6 (2-(1,3-dioxolan-2-yl)phenyl)(4-chlorophenyl)methanone 
• 122-01-0 4-chloro-benzoyl chloride 
• 536-40-3 4-chlorobenzoic acid hydrazide 
• 100622-79-5 4-chloro-N’-(2-hydroxybenzylidene)benzohydrazide 
• 122334-37-6 4-chloro-N-methoxy-N-methylbenzamide 
• 35822-58-3 2-bromobenzaldehyde diethyl acetal 

Downstream Products

• 22232-71-9 Mazindol 
• 23915-22-2 5-(4-chlorophenyl)-2,3-dihydro-5H-imidazo-[2,1-a]-isoindole 
• 41581-49-1 11-(4-chlorophenyl)-11H-isoindolo-[2,1-a]-benzoimidazole 
• 41581-45-7 11-(4-chloro-phenyl)-11H-benzo[4,5]imidazo[2,1-a]isoindol-11-ol 
• 22590-17-6 4'-chloro-2-(4,5-dihydro-1H-imidazol-2-yl)-benzophenone 
• 1599446-28-2 1-(4-chlorophenyl)-1,3-dihydroisobenzofuran 
• 57591-00-1 α-(4-chlorophenyl)-1,2-benzenedimethanol 

Relevant academic research and scientific papers

BF3-Etherate-catalyzed tandem reaction of 2-formylarylketones with electron-rich arenes/heteroarenes: An assembly of isobenzofurans

An efficient and BF3·Et2O-catalyzed chemoselective synthesis of diversified 1,3-diarylisobenzofuran in a high yield has been described. The reaction proceeds through sequential hydroarylation-cyclization between 2-formylarylketones and electron-rich arenes/heteroarenes. Advantageous features of the developed methodology include operational simplicity, a broad substrate scope, and applicability towards gram scale synthesis. The utility of isobenzofuran derivatives as the diene was extended to the synthesis of [4+2] cyclo-adducts with DMAD and the synthesis of 1,2-dicarbonylarenes in good yields.

Efficient synthesis of functionalized 1,3-dihydroisobenzofurans from salicylaldehydes: Application to the synthesis of escitalopram

An efficient synthesis of substituted 1,3-dihydroisobenzofurans is developed. In this novel route, o-aroylbenzaldehydes, as key intermediates, can be obtained by lead tetraacetate oxidation of N-aroylhydrazones of salicylaldehydes. The mild and general st

Cobalt-catalyzed enantioselective intramolecular hydroacylation of ketones and olefins

Cobalt-chiral diphoshine catalytic systems promote intramolecular hydroacylation reactions of 2-acylbenzaldehydes and 2-alkenylbenzaldehydes to afford phthalide and indanone derivatives, respectively, in moderate to good yields with high enantioselectivities. The ketone hydroacylation did not exhibit a significant H/D kinetic isotope effect (KIE) with respect to the aldehyde C-H bond, indicating that C-H activation would not be involved in the rate-limiting step.

Generation of functionalized aryl and heteroaryl aluminum reagents by halogen-lithium exchange

Various functionalized aryl and heteroaryl aluminum reagents were obtained by performing I-Li or Br-Li exchange reactions with the corresponding unsaturated organic halides in the presence of i-Bu2AlCl. By means of an appropriate catalyst, the

2,3-Dihydro-5-alkoxy-5-phenyl-5H-imidazo[2,1-a]isoindoles

Novel 2[2-(1,3-diazacycloalk-2-enyl)]benzophenone compounds and novel 1,3-diazacycloalkenyl[2,1-a]isoindole compounds having useful analgesic and psychostimulant properties are prepared inter alia by condensation of o-benzoylbenzaldehydes with aliphatic diamines.