23866-63-9Relevant academic research and scientific papers
Palladium-catalyzed N1-selective allylation of indoles with allylic alcohols promoted by titanium tetraisopropoxide
Chang, Chieh-Yu,Lin, Yu-Huan,Wu, Yen-Ku
supporting information, p. 1116 - 1119 (2019/01/29)
The direct N1-selective allylation of indoles with allylic alcohols has been accomplished by synergistic functions of palladium catalysts and titanium tetraisopropoxide. The site selectivity is notably different from that observed in other related transition metal-catalyzed approaches. This chemistry provides a facile route to a variety of allylated indoles in synthetically useful yields. The utility of this simple allylation reaction was demonstrated with the first total synthesis of (+)-N-(4′-hydroxyprenyl)-cyclo(alanyltryptophyl), which was completed in five steps, starting from l-tryptophan methyl ester hydrochloride.
One-pot synthesis of pharmacologically active diamines via rhodium- catalysed carbonylative hydroaminomethylation of heterocyclic allylic amines
Rische, Thorsten,Mueller, Kai-Sven,Eilbracht, Peter
, p. 9801 - 9816 (2007/10/03)
Pharmacologically active derivatives of phenothiazine, iminodibenzyl, carbazole and pyrazole are prepared with high yields and chemoselectivity by the reaction of the corresponding N-allylic or N-methallylic compounds, primary or secondary amines, carbon monoxide and hydrogen in the presence of [Rh(cod)Cl]2 as catalyst via a one pot hydroformylation - amine condensation - reduction sequence.
