238753-26-9

Basic information

• Product Name: (2R,4R)-1-benzyl-4-tert-butoxycarbonylamino-pyrrolidine-2,4-dicarboxylic acid dimethyl ester
• CAS NO: 238753-26-9
• Molecular Weight: 392.452
• Mol File: 238753-26-9.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (2R,4R)-1-benzyl-4-tert-butoxycarbonylamino-pyrrolidine-2,4-dicarboxylic acid dimethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (2R,4R)-1-benzyl-4-tert-butoxycarbonylamino-pyrrolidine-2,4-dicarboxylic acid dimethyl ester(238753-26-9)
• EPA Substance Registry System: (2R,4R)-1-benzyl-4-tert-butoxycarbonylamino-pyrrolidine-2,4-dicarboxylic acid dimethyl ester(238753-26-9)

Safety Data

• Hazardous Substances Data: 238753-26-9(Hazardous Substances Data)

Upstream product

• 171336-76-8 (2R,4R) 4-amino-1-(benzyl)-pyrrolidine-2,4-dicarboxylic acid 
• 2584-71-6 cis-hydroxy-D-proline 
• 911697-23-9 (R)-7-Benzyl-2,4-dioxo-1,3,7-triaza-spiro[4.4]nonane-8-carboxylic acid ethyl ester 
• 171192-72-6 (2R,4R)-ethyl N¹-benzyl-4-hydroxypyrrolidine-2-carboxylate 
• 171192-74-8 (2R)-ethyl N¹-benzyl-4-oxopyrrolidine-2-carboxylate 
• 100-39-0 benzyl bromide 
• 132666-67-2 (2S,4R)-ethyl 4-hydroxypyrrolidine-2-carboxylate 

Downstream Products

• 371979-33-8 (2R,4R)-4-tert-Butoxycarbonylamino-1-(2-phenylethynyl-benzyl)-pyrrolidine-2,4-dicarboxylic acid dimethyl ester 
• 371979-30-5 (2R,4R)-4-tert-Butoxycarbonylamino-1-(3,5-dinitro-benzyl)-pyrrolidine-2,4-dicarboxylic acid dimethyl ester 
• 371979-24-7 (2R,4R)-4-tert-Butoxycarbonylamino-1-(2-carboxy-benzyl)-pyrrolidine-2,4-dicarboxylic acid dimethyl ester 
• 371979-25-8 (2R,4R)-4-tert-Butoxycarbonylamino-1-(3-carboxy-benzyl)-pyrrolidine-2,4-dicarboxylic acid dimethyl ester 
• 371979-19-0 (2R,4R)-4-tert-Butoxycarbonylamino-1-(methoxycarbonyl-phenyl-methyl)-pyrrolidine-2,4-dicarboxylic acid dimethyl ester 
• 371979-28-1 (2R,4R)-4-tert-Butoxycarbonylamino-1-(3-nitro-benzyl)-pyrrolidine-2,4-dicarboxylic acid dimethyl ester 
• 371979-29-2 (2R,4R)-4-tert-Butoxycarbonylamino-1-(4-nitro-benzyl)-pyrrolidine-2,4-dicarboxylic acid dimethyl ester 
• 371979-27-0 (2R,4R)-4-tert-Butoxycarbonylamino-1-(2-nitro-benzyl)-pyrrolidine-2,4-dicarboxylic acid dimethyl ester 
• 371979-00-9 (2R,4R)-4-tert-Butoxycarbonylamino-1-(2-hydroxy-benzyl)-pyrrolidine-2,4-dicarboxylic acid dimethyl ester 
• 371979-22-5 (2R,4R)-4-tert-Butoxycarbonylamino-1-(4-methoxy-benzyl)-pyrrolidine-2,4-dicarboxylic acid dimethyl ester 

Relevant articles and documents

1-amino-APDC, a partial agonist of group II metabotropic glutamate receptors with neuroprotective properties

The synthesis of the 1-amino derivative of (2R,4R)-4-aminopyrrolidine- 2,4-dicarboxylic acid (1-amino-APDC), a selective metabotropic glutamate ligand, is disclosed. This compound acts as a partial agonist of the group II mGluRs and shows pronounced neuroprotective properties in the NMDA model of cell toxicity.

TRANS PYRROLIDINYL DERIVATIVES AND THEIR PHARMACEUTICAL USE

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